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Inefficacy of the commercial live oral Ty 21a vaccine in the prevention of typhoid fever

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Abstract

The efficacy of the live oral typhoid fever vaccine Ty 21a marketed in Switzerland in 1981 was investigated. Forty-seven Swiss travellers to Third World countries contracted typhoid fever in 1982 and 1983; 20 (43 %) of these persons had been vaccinated with Ty 21a. The incidence of typhoid fever in vaccinees was 1.1 per 10,000 doses of Ty 21a vaccine sold, which was similar to the incidence of 0.9 per 10,000 doses for the ineffective killed Ty 2 vaccine. Comparison of the incidence of vaccination in patients with typhoid fever in 1983 and in healthy travellers to India revealed vaccination efficacy rates which were not significantly different from zero. It is suggested that Ty 21a vaccine in the form marketed in Switzerland in 1981–1983 is not sufficiently potent or heat-stable, so that the doses of viable bacteria ingested were too low.

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References

  1. Ashcroft, M. T., Singh, B., Nicholson, C. C., Ritchie, J., Sobrian, E., Williams, F.: A seven-year field trial of two typhoid vaccines in Guyana. Lancet 1967, ii: 1056–1059.

    Google Scholar 

  2. Chuttani, C. S., Prakash, K., Gupta, P., Grover, V., Kumar, A.: Controlled field trial of a high-dose oral killed typhoid vaccine in India. Bulletin of the World Health Organization 1977, 55: 643–644.

    PubMed  Google Scholar 

  3. Gilman, R. H., Hornick, R. B., Woodward, W. E., DuPont, H. L., Jr., Levine, M. M., Libonati, J. P.: Evaluation of a UDP-glucose-4-epimeraseless mutant ofSalmonella typhi as a live oral vaccine. Journal of Infectious Diseases 1977, 136: 716–723.

    Google Scholar 

  4. Wahdan, M. H., Sérié, C., Cerisier, Y., Sallam, S., Germanier, R.: A controlled field trial of liveSalmonella typhi strain Ty 21a vaccine against typhoid: three-year results. Journal of Infectious Diseases 1982, 145: 308–314.

    Google Scholar 

  5. Hirschel, B. J., Hirschel-Scholz, S., Lüthi, R., Bonetti, A.: Typhus abdominalis nach Impfung mit dem Lebend-Impfstoff Vivotif. Schweizerische medizinische Wochenschrift 1983, 113: 605–607.

    PubMed  Google Scholar 

  6. Anonymous: Measles vaccine efficacy. United States Morbidity and Mortality Weekly Report 1980, 29: 470–472.

  7. Greenwood, M., Yule, G.: The statistics of anti-typhoid and anti-cholera inoculations. Proceedings of the Royal Society of Medicine 1915, 8: 113–194.

    Google Scholar 

  8. Armitage, P.: Statistical methods in medical research. Blackwell, Oxford, 1980, p. 427–431.

    Google Scholar 

  9. Taylor, D. N., Pollard, R. A., Blake, P. A.: Typhoid in the United States and the risk to the international traveller. Journal of Infectious Diseases 1983, 148: 599–603.

    PubMed  Google Scholar 

  10. Woodward, T. E., Woodward, W. E.: A new oral vaccine against typhoid fever. Journal of Infectious Diseases 1982, 145: 289–291.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Division des Maladies Infectieuses, Hôpital Cantonal Universitaire, 1211, Genève 4, Switzerland

    B. Hirschel & R. Wüthrich

  2. Federal Office of Public Health, Bollwerk 29, 3000, Bern, Switzerland

    B. Somaini

  3. Institute for Social and Preventive Medicine, 8006, Zurich, Switzerland

    R. Steffen

Authors
  1. B. Hirschel
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  2. R. Wüthrich
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  3. B. Somaini
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  4. R. Steffen
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Hirschel, B., Wüthrich, R., Somaini, B. et al. Inefficacy of the commercial live oral Ty 21a vaccine in the prevention of typhoid fever. Eur. J. Clin. Microbiol. 4, 295–298 (1985). https://doi.org/10.1007/BF02013656

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  • DOI: https://doi.org/10.1007/BF02013656

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