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Changes of local cerebral glucose utilization, DC potential and extracellular potassium concentration in experimental head injury of varying severity

  • Head Injuries
  • Recent advances in experimental and clinical work Cerebral blood flow Biochemistry Outcome in children and in the elderly
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Summary

The negative shift of DC potential was associated with an increase of extracellular potassium and energy metabolism. Therefore this dramatic phenomenon following the trauma to the brain was thought to be identical to spreading depression.

  1. 1.

    Spreading depression was most frequently observed between one and two hours after injury.

  2. 2.

    Spreading depression can be elicited in the deep structures as well as in the cortex. The more severe the injury, the more frequently the negative shifts were observed. The DC index seems to correlate well with the severity of the experimental model.

It is concluded that the energy metabolism after the brain contusion was different from structure to structure and was changing continuously in the course of time.

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References

  1. A.J. Hansen and M. Nedergaad: Interstitial ion activities in cerebral ischemia. Sendai Forum '86 October, 27, 28, Matsushima, Japan, 1986

  2. A.A.P. Leao: Spreading depression of activity in the cerebral cortex. J. Neurophysiol. 7: 359–390, 1944

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Authors and Affiliations

  1. Department of Neurological Surgery, School of Medicine Chiba University, Inohana 1-8-1, 280, Chiba, Japan

    Kubota M, T. Nakamura, K. Sunami, Y. Ozawa, H. Namba, A. Yamaura & H. Makino

Authors
  1. Kubota M
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  2. T. Nakamura
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  3. K. Sunami
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  4. Y. Ozawa
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  5. H. Namba
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  6. A. Yamaura
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  7. H. Makino
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Kubota, M., Nakamura, T., Sunami, K. et al. Changes of local cerebral glucose utilization, DC potential and extracellular potassium concentration in experimental head injury of varying severity. Neurosurg. Rev. 12 (Suppl 1), 393–399 (1989). https://doi.org/10.1007/BF01790681

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  • DOI: https://doi.org/10.1007/BF01790681

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