Summary
Utilizing multiperforated capsules implanted into subcutaneous tissue and the prostate in dogs, the concentration of cephalothin in soft tissue interstitial fluid (STIF) and prostatic interstitial fluid (PIF) was measured simultaneously and compared with concentration in serum. At all times the antibiotic concentration in PIF was lower than levels found in STIF and serum. This model may aid in the understanding of the basic pharmocokinetics of antibiotics in the prostatic interstitium and provide guidelines for treatment of prostatitis.
Zusammenfassung
Mittels implantierter perforierter Kapseln wurde die Konzentration von Cephalotin in der interstitiellen Flüssigkeit des Subkutangewebes (STIF) und der Prostata (PIF) gemessen und mit dem Serumspiegel verglichen. Die Antibiotikakonzentration im PIF war zu allen Zeiten niedriger als im STIF oder Serum. Dieses Modell trägt zum grundsätzlichen Verständnis der Pharmakokinetik im Prostatainterstitium bei und kann bei der Behandlung der Prostatitis Richtlinien geben.
Similar content being viewed by others
Literature
Armstrong, J. R., Cook, F. E., Robinson, J. R. Concentration of antibiotic and chemotherapeutic agents in the ejaculum. J. Urol. 100 (1968) 72.
Blacklock, N. J. Anatomical factors in prostatitis. Brit. J. Urol. 46 (1974) 47.
Drach, G. W. Problems in diagnosis of bacterial prostatitis: gram-negative, gram-positive and mixed infections. J. Urol. 111 (1974) 630.
Eickenberg, H.-U., Scharfenberger, L., Waterman, N. G. Concentration of antibiotics in renal interstitial fluid: An experimental model. Urol. Res. 4 (1975) 1.
Kunin, C. M. Inhibitors of penicillin binding to serum proteins. J. Lab. Clin. Med. 65 (1965) 416.
Meares, E. M., Stamey, T. A. Bacteriologic localization patterns in bacterial prostatitis and urethritis. Invest. Urol. 5 (1968) 492.
Schmidt, J. D., Patterson, M. C. Needly biopsy study of chronic prostatitis. J. Urol. 96 (1966) 519.
Stamey, T. A., Meares, E. M., Jr., Winningham, D. G. Chronic bacterial prostatitis and the diffusion of drugs into prostatic fluid. J. Urol. 103 (1970) 187.
Waterman, N. G., Kastan, L. B. Interstitial fluid and serum antibiotic concentrations. Arch. Surg. 105 (1972) 192.
Waterman, N. G., Scharfenberger, L. Hepatic interstitial and wound fluid antibiotic concentrations. Surg. Gynecol. Obstet. 142 (1976) 235.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Eickenberg, H.U., Scharfenberger, L. & Waterman, N.G. A new model for measuring concentration of antibiotics in prostatic interstitial fluid. Infection 4 (Suppl 2), S108–S112 (1976). https://doi.org/10.1007/BF01674479
Issue Date:
DOI: https://doi.org/10.1007/BF01674479