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Synergismus von Netilmicin und anderen Aminoglykosiden mit Cefotaxim gegen nosokomiale, nicht fermentierende Erreger

The synergism of netilmicin and other aminoglycosides with cefotaxime against nosocomial, non-fermenting causative agents

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Zusammenfassung

Mit der Checkerboard-Agar-Dilutionsmethode wurde die Kombinationswirkung von Cefotaxim mit Netilmicin und anderen Aminoglykosiden gegen 57 nicht fermentierende gramnegative Bakterien (Pseudomonas aeruginosa, Pseudomonas cepacia, Pseudomonas maltophilia, Pseudomonas fluorescensputida, Acinetobacter anitratus, Acinetobacter lwoffi) überprüft, die von Patienten mit im Krankenhaus erworbenen Infektionen isoliert worden waren. Durchschnittlich 39% der Nonfermenter wurden durch Cefotaxim-Aminoglykosid-Kombinationen additiv, 14% synergistisch gehemmt. Die additive und synergistische Wirkung war am besten beiP. aeruginosa, P. maltophilia undP. fluorescens-putida Stämmen, am niedrigsten gegenAcinetobacter Spezies; gegenP. cepacia Stämme trat kein Synergismus auf. Die additiven und/oder synergistischen Kombinationen senkten die minimalen Hemmkonzentrationen von Cefotaxim, Netilmicin und anderen Aminoglykosiden bei fast allen Stämmen auf therapeutisch erreichbare Serumkonzentrationen.

Summary

Using the checkerboard agar dilution method, the combined effect of cefotaxime with netilmicin and other aminoglycosides on 57 non-fermenting, gram-negative bacteria (Pseudomonas aeruginosa, Pseudomonas cepacia, Pseudomonas maltophilia, Pseudomonas fluorescensputida, Acinetobacter anitratus, Acinetobacter lwoffi) was tested. These bacteria had been isolated from patients with nosocomial infections. An average of 39% of the non-fermenting bacteria were inhibited by the additive effect of cefotaxime-aminoglycoside combinations. 14% on the average by the synergistic effect. The additive and synergistic effect was greatest againstP. aeruginosa, P. maltophilia andP. fluorescens-putida strains and weakest againstAcinetobacter species. No synergism was found withP. cepacia strains. The additive and/or synergistic combinations reduced the minimal inhibitory concentrations of cefotaxime, netilmicin and other aminoglycosides to therapeutically attainable serum concentrations for nearly all strains.

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Authors and Affiliations

  1. Klinikhygiene in der Universität Freiburg, Hugstetterstraße 55, D-7800, Freiburg

    F. D. Daschner, A. Steffens,  M. Just &  M. Metzger

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  1. F. D. Daschner
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  2. A. Steffens
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  3. M. Just
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  4. M. Metzger
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Daschner, F.D., Steffens, A., Just, M. et al. Synergismus von Netilmicin und anderen Aminoglykosiden mit Cefotaxim gegen nosokomiale, nicht fermentierende Erreger. Infection 8 (Suppl 4), S433–S436 (1980). https://doi.org/10.1007/BF01639413

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