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Clinical evaluation of cefadroxil: A multicenter trial. II. Urinary tract infections

Klinische Prüfung von Cefadroxil: Eine multizentrische Studie II Harnwegsinfektionen

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Summary

Cefadroxil, a new semi-synthetic broad-spectrum cephalosporin, was administered to 144 patients with acute (64.6%) and chronic (35.4%) urinary tract infections. An excellent correlation was found between clinical response (cured+improved=82.6%) and bacteriological eradication of the causative organism (88.9%). The drug was very well tolerated, even after prolonged administration (up to 23 days): side-effects only appeared in 6 cases (=4.2%), two of which were rashes (=1.4%). In one of the participating laboratories, 22 (=35%) of the pre-treatment isolated strains were found to be resistant to ampicillin or derivatives: all of these 22 strains proved to be sensitive towards cefadroxil.

Zusammenfassung

Cefadroxil, ein neues, halbsynthetisches Breitspektrum-cephalosporin wurde 144 Patienten mit akuten (64,6%) und chronischen (35,4%) Harnwegsinfektionen verabreicht. Eine hervorragende Korrelation bestand zwischen klinischem Ansprechen (geheilt+gebessert=82,6%) und der Elimination der verantwortlichen Erreger (88,9%). Das Medikament wurde sehr gut vertragen, auch nach Langzeitanwendung (bis zu 23 Tagen): Nebenwirkungen traten nur bei sechs Fällen auf (4,2%), zwei davon waren Exantheme (1,4%). In einem der beteiligten Laboratorien wurde festgestellt, daß 22 (35%) der vor der Behandlung isolierten Stämme gegen Ampicillin oder seine Derivate resistent waren: alle diese 22 Stämme zeigten sich gegenüber Cefadroxil sensibel.

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Authors and Affiliations

  1. Int. Med. Dept., Kortenberg, Academic Psychiatric Hospital St. Jozef, Leuven

    J. Reynaert

  2. Bact. Dept., Academic Hospital St. Raphael, Leuven

    J. Vandepitte

  3. Urological Dept., Gent, Academic Hospital, Belgium

    R. Desmet

  4. Urological Dept., Hospital H. Serruys, Oostende

    J. Casselman

  5. Surgical Dept., Clinic H. Hart, Tienen

    H. Lerut

  6. Gent

    M. Castro

  7. Laboratory for Pharmac. Microbiology, State University Gent, Belgium

    J. Pijck, A. Vuye & Th. Hallynck

Authors
  1. J. Reynaert
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  2. J. Vandepitte
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  3. R. Desmet
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  4. J. Casselman
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  5. H. Lerut
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  6. M. Castro
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  7. J. Pijck
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  8. A. Vuye
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  9. Th. Hallynck
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Additional information

Erstveröffentlichung: Drugs Exptl. clin. Res. 4 (1978) 95.

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Reynaert, J., Vandepitte, J., Desmet, R. et al. Clinical evaluation of cefadroxil: A multicenter trial. II. Urinary tract infections. Infection 8 (Suppl 5), S617–S622 (1980). https://doi.org/10.1007/BF01639682

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  • DOI: https://doi.org/10.1007/BF01639682

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