Summary
We evaluated the serum concentrations of zinc., copper and selenium in 125 patients with juvenile chronic arthritis (JCA). Trace element levels showed distinct abnormalities as compared with those of a large group of healthy children. Serum zinc and selenium concentrations were lower and those of copper higher in children with arthritis than in healthy children and, further, patients with polyarthritis had significantly higher copper and lower zinc levels than those with oligoarthritis. Serum zinc levels showed a direct correlation with hemoglobin and an inverse correlation with values for the erythrocyte sedimentation rate (ESR), whereas copper correlated directly with ESR. Selenium values did not correlate with the activity of the disease, but were low in the patients with arthritis of long duration.
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Lunec., J., Halloran, S.P., White, A.G., Dormandy, T.L. Free radical oxidation products in serum and synovial fluid in rheumatoid arthritis. J Rheumatol 1981, 8, 233–245.
Halliwell B., Gutteridge J.M.C., Lipid peroxidation, oxygen free radicals, cell damage and antioxidant therapy. Lancet 1986, 2, 1396.
Vapaatalo, H. Free radicals and anti-inflammatory drugs. Med Biol 1986, 64, 1–7.
Biemond, B., Swaak, A.J.G., Koster, J.F., Protective factors against oxygen free radicals and hydrogen peroxide in rheumatoid arthritis synovial fluid. Arthritis Rheum 1984, 27, 760–766.
Sorenson, J.R.J. An evaluation of altered copper, iron, magnesium, manganese and zinc concentrations in rheumatoid arthritis. Inorganic perspectives in biology and medicine 1978, 2, 1–26.
Scudder, P.R., Al-Timmi, D., McMurray, W., White, A.G., Zoob, B.C., Dormandy, T.L. Serum copper and related variables in rheumatoid arthritis. Ann Rheum Dis 1978, 37, 67–70.
Gutteridge, J.M.C., Hill, C., Blake, D.R. Copper stimulated phospholipid membrane peroxidation. Antioxidant activity of serum and synovial fluid from patients with rheumatoid arthritis. Clin Chim Acta 1984, 139, 85–90.
Sunde, R.A., Hoekstra, W.G., Structure, synthesis and function of glutathione peroxidase. Nutr Rev 1980, 38, 265.
Tarp, U., Overvad, K., Hansen, J.C., Thorling, E.B. Low serum selenium in severe rheumatoid arthritis. Scand J Rheumatol 1985, 14, 97–101.
Svantesson, H., Johansson, U., Portinsson, S., Akesson, A., Akesson, B., Ockerman, P.A. Low plasma selenium (Se), in juvenile chronic arthritis (JCA). Scand J Rheumatol 1984, 53 (suppl.), 94.
Mäkelä, A.L., Hyörä, H., Vuorinen, K., Näntö, V. Trace elements (Fe, Zn, Cu, and Se) in serum of rheumatic children living in western Finland. Scand J Rheumatol 1984, 53 (suppl.), 94.
Youssef, A.A.R., Baron, D. Leucocyte Superoxide dismutase in rheumatoid arthritis. Ann Rheum Dis 1983, 42, 558–562.
Balogh, Z., El-Ghobarey, A.F., Fell, G.S., Brown, D.H., Dunlop J., Dick, W.C. Plasma zinc and its relationship to clinical symptoms and drug treatment in rheumatoid arthritis. Ann Rheum Dis 1980, 39, 329–332.
Bonebrake, R.A., McCarr, J.T., Hunder, G.C., Polley, H.F. Zinc accumulation in synovial fluid. Mayo Clin Proc 1972, 47, 448–452.
Ambanelli, U., Ferracioli, G.F., Troise, W., Serventi, G. Die Zink Konzentration in Blut und Synovia im Verlauf der Chronischen Polyarthritis; Korrelationen mit Eisen und den Transportproteinen (Alpha-2-Macroglobulin; Transferrin). Z Rheumathol 1977, 36, 345–350.
Brewer, E.J., Bass, J., Baum, J., Cassidy, J.T., Fink, C., Jacobs, J., Hanson, V., Levinson, J.E., Schaller, J., Stillman, J.S. A current proposed revision of JRA criteria. Arthritis Rheum 1977, 20 (suppl.), 183–185.
Salmela, S.S., Vuori, E. Improved direct determination of copper and zinc in a single serum dilution by atomicabsorption spectrophotometry. At spectrosc 1984, 5, 146–149.
Alfthan, G., Kumpulainen, J. Determination of selenium in small volumes of blood plasma and serum by electrothermal atomic absorption spectrometry. Anal Chim Acta, 1985, 140, 21.
Mancini, G., Garbonara, A.O., Hereman, J.F. Immunochemical quantitation of antigen by single radial immunodiffusion. Immunochemistry 1965, 2, 235–254.
Siimes, M.A., Wang, W.L., Dallman, P.R. Elevated serum ferritin in children with malignancies. Scand J Haematol 1977, 19, 153–158.
Vuori, E., Salmela, S., Åkerblom, H.K., Viikari, J., Uhari, M., Suoninen, P., Pietikäinen, M., Pesonen, E., Lähde, P.L., Dahl, M. Atherosclerosis precursors in Finnish children and adolescents. XIII. Serum and hair copper and zinc concentrations. Acta Paediatr Scand 1985, 318 (suppl.), 205–212.
Engelman, L., Stepwise logistic regression. In: BMDP Statistical Software. Editor: Dixon W.J., University of California Press, Berkeley, California, 1985, 330–345.
Harvey, A.R., Pippard, M.J., Ansell, B.M. Microcytic anaemia in juvenile chronic arthritis. Scand J Rheumatol 1987, 16, 53–59.
Mallya, R.K., De Beer, F.C., Berry, H., Hamilton, E.D.B., Mace B.E.W., Bebys, M.B. Correlation of clinical parameters of disease activity in rheumatoid arthritis with serum concentration of C-reactive protein and erythrocyte sedimentation rate. J Rheumatol 1982, 9, 224–228.
Pelkonen, P., Swanljung, K., Siimes, M.A. Ferritinemia as an indicator of systemic disease activity in children with systemic juvenile rheumatoid arthritis. Acta Paediatr Scand 1986, 75, 64–68.
Beisel, W.R., Pekarek, R.S., Wannemacher, R.W. Homeostatic mechanisms affecting plasma zinc levels in acute stress, In: Trace elements in human health and disease I, Editors: Prasad, A.S., Oberleas, D., New York Academic Press, New York, 1976, 87.
Van Campen, D.R. Copper interference with the intestinal absorption of zinc-65 by rats. J Nutr 1969, 97, 104.
Yunice, A., Czerwinski, A.W., Lindeman, R.D. Influence of synthetic corticosteroids in plasma zinc and copper levels in humans. Am J Med Sci, 1981, 282, 68–74.
Ambanelli, U., Ferracioli, G.F., Serventi, G., Vaona, G.L. Changes in serum and urinary zinc induced by ASA and indomethacin. Scand J Rheumatol, 1982, 11, 63–64.
Mussalo-Rauhamaa, H., Lehto, J. Suomalaisten seerumin seleenipitoisuus nyt kansainvälisellä tasolla. Suomen Lääkärilehti 1987, 24, 2204–2205.
Tarp, U., Overvad, K., Thorling, E.B., Grandal, H., Hansen, J.C., Selenium treatment in rheumatoid arthritis. Scand J Rheumatol 1985, 14, 364–368.
Munthe, E., Aaseth, J. Treatment of rheumatoid arthritis with selenium and vitamin E. Scand J Rheumatol 1984, 53 (suppl.), 103.
Tarp, U., Hansen, J.C., Overvad, K., Thorling, E.B., Tarp, B.D., Graudal, H. Glutathione peroxidase (GSHpx) in rheumatoid arthritis: Effect of selenium (Se) supplementation. Scand J Rheumatol 1986, 59 (suppl.), 76.
Kushner, I., Somerville, J.A., Permeability of human synovial membrane to plasma proteins. Arthritis Rheum 1971, 14, 560–569.
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Honkanen, V., Pelkonen, P., Mussalo-Rauhamaa, H. et al. Serum trace elements in juvenile chronic arthritis. Clin Rheumatol 8, 64–70 (1989). https://doi.org/10.1007/BF02031072
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DOI: https://doi.org/10.1007/BF02031072