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The effect of organochlorine insecticides on serum cholesterol level in people occupationally exposed

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Summary

Serum cholesterol was determined in 206 workers occupationally exposed to organochlorine insecticides (OCI) and in 86 workers non-occupationally exposed to these chemicals.

In both groups of workers the serum cholesterol level increased with age. The increase was greater in exposed workers but the difference between the two groups was statistically significant only in the over 45 years age group.

It is thought that OCI induce an increase of cholesterol synthesis, but this process is masked by a concomitant breakdown. In the over 45 years age group a diminished reactivity of homeostatic processes may explain the finding of enhanced cholesterol synthesis which is no longer masked by concomitant catabolism.

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Authors and Affiliations

  1. Hadassah Medical School Jerusalem, Department of Occupational Health, The Hebrew University, Jerusalem, Israel

    M. Wassermann, Dora Wassermann, Ita Aronovski, I. Ivriani & Debora Rosenfeld

Authors
  1. M. Wassermann
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  2. Dora Wassermann
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  3. Ita Aronovski
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  4. I. Ivriani
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  5. Debora Rosenfeld
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Additional information

Supported by Grant 06-004-3 from the U.S.A. Department of Health, Education and Welfare, Public Health Service, Bureau of Occupational Safety and Health, Environmental Control Administration.

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Wassermann, M., Wassermann, D., Aronovski, I. et al. The effect of organochlorine insecticides on serum cholesterol level in people occupationally exposed. Bull. Environ. Contam. Toxicol. 5, 368–372 (1970). https://doi.org/10.1007/BF01539952

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