Skip to main content
SpringerLink
Log in

Effect of synthetic humic acid-multimetal complex on human plasma prothrombin time

  • Published:
Bulletin of Environmental Contamination and Toxicology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Chen KP, Wu HY (1962) Epidemiologic studies on blackfoot disease: a study of source of drinking water in relation to the disease. J Formosan Med Assoc 61:611–618.

    Google Scholar 

  • Chiu HC, Shih SR, Lu FJ, Yang HL (1993) Stimulation of endothelin production in cultured human endothelin cells by fluorescent compounds associated with Blackfoot disease Thromb Res 69:139–151.

    Google Scholar 

  • Hannien KI, Klocking R, Heibig B (1987) Synthesis and characterization of humic acid-like polymers. Sci Total Environ 62:201–210.

    Google Scholar 

  • Lu FJ, Yamamura Y, Yamauchi H (1988) Studies on fluorescent compounds in water of a well in the endemic areas of blackfoot disease in Taiwan: Humic substances. J Formosan Med Assoc 87:66–75.

    Google Scholar 

  • Lu FJ (1990a) Fluorescent humic substances and blackfoot disease in Taiwan. Appl Organometallic Chemistry 4:191–195

    Google Scholar 

  • Lu FJ (1990b) Arsenic as a promoter in the effect of humic substances on plasma prothrombin time in vitro. Thromb Res 58:537–541.

    Google Scholar 

  • Lu FJ (1990c) Blackfoot disease: arsenic or humic acid? Lancet 336: 115–116.

    Google Scholar 

  • Lu FJ, Shih SR, Liu TM, Shown SH (1990) The effect of fluorescent humic substances existing in the well water of blackfoot disease endemic areas in Taiwan on prothrombin time and activated partial thromboplastin time in vitro. Thromb Res 57:747–753.

    Google Scholar 

  • Lu FJ, Lee YS (1992) Humic acid: inhibitor of plasmin. Sci Total Environ 114:135–139.

    Google Scholar 

  • Tseng WP, Chen WY, Sung JL, Chen JS (1961) A clinical study of blackfoot disease in Taiwan: An endemic peripheral vascular disease. Memoirs Coll Med Nat Taiwan Univ 7:1–8.

    Google Scholar 

  • Wang TSC, Li SW (1976) Clay minerals as hetergenous catalysts in preparation of model humic substances. Z Pflanzenernaehr Bodenkd 140:669–676.

    Google Scholar 

  • Yu JJ (1982). Study on the deposition of humic acid in rat bone. Proceeding national conference on medical applications of humic acid, p 83–84.

  • Zhai SS, Kimbrough RD, Meng B, Han JY, Levoid M, Hou X and Yin XN (1990). Kashin-Beck disease: a cross-sectional study in seven villages in the Peoples' Republic of China. J Toxicol Environ Health 30:239–259.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Medicine, National Taiwan University, 1 sec 1 Jen-Ai Road, Taipei, Taiwan, China

    F. -J. Lu & J. -H. Lee

  2. Department of Biochemistry and Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, China

    T. -S. Huang

Authors
  1. F. -J. Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. -S. Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. -H. Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lu, F.J., Huang, T.S. & Lee, J.H. Effect of synthetic humic acid-multimetal complex on human plasma prothrombin time. Bull. Environ. Contam. Toxicol. 53, 577–582 (1994). https://doi.org/10.1007/BF00199029

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00199029

Keywords

Search

Navigation