Abstract
A mean concentration of 2.4×10−8 g U/g ash has been obtained for normal human bone The microdistribution of uranium in bone indicates that this element is mainly restricted to endosteal surfaces; in particular the surfaces of trabecular bone and the walls of open Haversian canals in cortical bone. This distribution suggests that uranium is present in a chemical form that is not acceptable for incorporation into bone apatite and consequently there does not appear to be a significant diffuse distribution of uranium throughout bone.
Résumé
Une concentration moyenne de 2.4×10−8 g U/g de cendre a été obtenue à partir de l'os humain normal. La microdistribution de l'uranium dans l'os indique que cet élément est surtout limité à surface de l'endoste et, en particulier, aux surfaces de l'os lamellaire et aux parois des canaux de Havers, ouverts dans l'os corticol. Cette répartition suggère que l'uranium se présente sous une forme chimique impropre à son incorporation dans l'apatite osseux: il ne semble donc pas exister une distribution diffuse significative de l'uranium dans l'os.
Zusammenfassung
Eine mittlere Konzentration von 2,4×10−8 g Uran/g Asche wurde in normalen menschlichen Knochen gefunden. Die Feinverteilung von Uran im Knochen zeigt, daß dieses Element hauptsächlich an der endostalen Oberfläche vorkommt, insbesondere an der Oberfläche des trabeculären Knochens und an den Wänden der offenen Haversschen Kanäle im kortikalen Knochen. Diese Verteilung läßt vermuten, daß Uran in einer chemischen Form vorliegt, welche sich für den Einbau in das Knochenapatit nicht eignet. Daraus folgt, daß keine signifikante diffuse Verteilung des Urans innerhalb des Knochens vorliegt.
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References
Amiel, S.: Analytical applications of delayed neutron emission in fissionable elements. Israel AEC, E-1A 621,58 (1961).
Borasky, R.: Collagen reactivity with plutonium. In: Research Ann. Rept. (1956) USAEC Rept. H. W. 47 500, Hanford Atomic Products Op. GEC, p. 36–41 (1957).
Chipperfield, A. R., Taylor, D. M.: Binding of plutonium and americium to bone glycoproteins. Nature (Lond.)219, 609 (1968).
Fleischer, R. L.: Uranium micromaps: technique for in situ mapping of distribution of fissionable impurities. Rev. Sci. Instruments37, 1738–1739 (1966).
—, Lovett, D. B.: Uranium and boron content of water oy particle track etching. Geochim. cosmochim. Acta32, 1126–1128 (1968).
—, Price, P. B., Walker, R. M.: Method of forming fine holes of near atomic dimensions. Rev. Sci. Instruments34, 510–512 (1963).
Hamilton, E. I.: Applied geochronology. London and New York: Academic Press 1965.
—: A new approach to autoradiography in the life sciences. The determination of radionuclides in materials of biological origin. Proc. Symp. AERE, R-5474, 155–162 (1967).
—: The concentration of uranium in air from contrasted natural environments. Hlth Phys.19, 511–520 (1970a).
—: Uranium content of normal blood. Nature (Lond.)227, 501 (1970b).
Hamilton, E. I.: The concentration of uranium in man and his diet. In preparation (1970c).
Kisieleski, W. E., Faraghan, W. G., Norris, W. P., Arnold, J. G.: The metabolism of uranium-233 in mice. J. Pharmacol. exp. Ther.104, 459–467 (1952).
Kleeman, J. D., Lovering, J. F.: Lexan plastic prints: how they are formed. Proc. Int. Conf. on Nuclear Track Registration in Insulating Solids and Applications, Clermont Ferrand 1969, vol. 2, 41–52.
Lal, D., Muralli, A. V., Rajan, R. S., Tamhane, A. S., Lorin, J. C., Pellas, P.: Techniques for proper revelation and viewing of etch-tracks in meteoritic and terrestrial minerals. Earth and Planetary Science Letters5, 111–119 (1968).
Magno, P. J., Kauffman, P. E., Shleien, B.: Plutonium in environmental and biological medicine. Hlth Phys.13, 1325–1330 (1967).
Marshall, J. H.: Measurements and models of skeletal metabolism. In: Mineral metabolism (C. L. Comar and F. Bronner, eds.), vol. III: Calcium physiology, p. 1–122. New York and London: Academic Press 1969.
Neuman, W. F., Neuman, M. W.: The chemical dynamics of bone mineral. Chicago: Chicago University Press 1958.
Richelle, L. J., Onkelinx, C.: Recent advances in the physical biology of bone and other hard tissue. In: Mineral metabolism (C. L. Comar and F. Bronner, eds.), vol. III: Calcium physiology, p. 123–190. New York and London: Academic Press 1969.
Rowland, R. E., Farnham, J. E.: The deposition of uranium in bone. Argonne Nat. Lab. Ann. Rept. ANL 7 489, 33–36 (1968).
Welford, A. G. A., Baird, R.: Uranium levels in human diet and biological materials. Hlth Phys.13, 1321–1324 (1967).
Williams, P. A., Peacocke, R. A.: Binding of calcium, yttrium, and thorium to a glycoprotein from bovine cortical bone. Nature (Lond.)211, 1140 (1966).
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This work is part of a programme of work undertaken by the Radiological Protection Service which is supported by the Medical Research Council and the Department of Health and Social Security.
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Hamilton, E.I. The concentration and distribution of uranium in human skeletal tissues. Calc. Tis Res. 7, 150–162 (1971). https://doi.org/10.1007/BF02062603
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DOI: https://doi.org/10.1007/BF02062603