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Aldicarb immunomodulation in mice: An inverse dose-response to parts per billion levels in drinking water

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Abstract

The effects of aldicarb (a carbamate insecticide and nematocide) on selected immune and non-immune parameters of mice were examined. The primary objective was to determine whether exposure to low levels of aldicarb through drinking water could affect selected immune functions. Aldicarb was administered via drinking water either at 10, 100, and 1,000 parts per billion (ppb)2 for 14 days or at 1, 10, 100, and 1,000 ppb for 34 days. The 34-day experiment was repeated twice with minor variations. Aldicarb significantly and repeatedly suppressed the splenic plaque forming cell response to sheep red blood cells at the lowest concentrations tested: the 1 ppb level elicited greater suppression of plaque forming cells and other immune factors than did 1,000 ppb of aldicarb. This inverse dose-response represents a dramatic departure from the classic toxicologic dose-response curve, where toxicity increases with increasing dose levels.

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Author notes

  1. Leon John Olson

    Present address: Wisconsin Department of Health and Social Services, Division of Health, Room 325, 1 West Wilson Street, 53702, Madison, Wisconsin

Authors and Affiliations

  1. Departments of Bacteriology, University of Wisconsin, 53706, Madison, Wisconsin

    Leon John Olson, Ronald D. Hinsdill & Richard C. Bidgood

  2. Departments of Entomology, University of Wisconsin, 53706, Madison, Wisconsin

    Barbara J. Erickson & Jeffrey A. Wyman

  3. Departments of Horticulture, University of Wisconsin, 53706, Madison, Wisconsin

    Larry K. Binning

  4. Departments of Zoology, University of Wisconsin, 53706, Madison, Wisconsin

    Warren P. Porter

  5. Departments of Statistics, University of Wisconsin, 53706, Madison, Wisconsin

    Erik V. Nordheim

Authors
  1. Leon John Olson
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  2. Barbara J. Erickson
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  3. Ronald D. Hinsdill
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  4. Jeffrey A. Wyman
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  5. Warren P. Porter
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  6. Larry K. Binning
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  7. Richard C. Bidgood
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  8. Erik V. Nordheim
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Olson, L.J., Erickson, B.J., Hinsdill, R.D. et al. Aldicarb immunomodulation in mice: An inverse dose-response to parts per billion levels in drinking water. Arch. Environ. Contam. Toxicol. 16, 433–439 (1987). https://doi.org/10.1007/BF01055264

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  • DOI: https://doi.org/10.1007/BF01055264

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