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Acute toxicity of methyl isocyanate in mammals. II. Induction of hyperglycemia, lactic acidosis, uraemia, and hypothermia in rats

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Abstract

When rats were administered methyl isocyanate (MIC) by inhalation or subcutaneous route it produced severe hyperglycemia, clinical lactic acidosis, highly elevated plasma urea, and reduced plasma cholinesterase activity with unaltered erythrocytc acetyl cholinesterase activity. Irrespective of the route of administration, MIC also caused severe hypothermia, which was not ameliorated by prior administration of atropine sulphate. Acute toxic effects of MIC are essentially similar by either route except for the intensity of the effects.

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Authors and Affiliations

  1. Division of Pharmacology and Toxicology, Defence R&D Establishment, Gwalior, India

    K. Jeevaratnam & R. Vijayaraghavan

  2. Division of Chemistry, Defence R&D Establishment, Gwalior, India

    M. P. Kaushik

  3. Department of Biochemistry, Indian Institute of Science, Bangalore, India

    C. S. Vaidyanathan

Authors
  1. K. Jeevaratnam
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  2. R. Vijayaraghavan
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  3. M. P. Kaushik
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  4. C. S. Vaidyanathan
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Additional information

For Part I see Jeevarathinamet al. (1988) Toxicology 51:223–240.

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Jeevaratnam, K., Vijayaraghavan, R., Kaushik, M.P. et al. Acute toxicity of methyl isocyanate in mammals. II. Induction of hyperglycemia, lactic acidosis, uraemia, and hypothermia in rats. Arch. Environ. Contam. Toxicol. 19, 314–318 (1990). https://doi.org/10.1007/BF01054971

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  • DOI: https://doi.org/10.1007/BF01054971

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