Abstract
3-Chloro-4-methyl benzamine HCl (DRC-1339), an avian toxicant, was fed to five species of birds for periods up to 120 days. The 30-day LC50 of uniformly treated feed for starlings was 4.7 ppm and the 90-day LC50 was 1.0 ppm. The 28-day LC50 for coturnix was 18 ppm. The 30-day LC50 for pigeons was less than 100 ppm. Pheasants fed diets containing 2% DRC-1339 baits diluted to a rate of 286 ppm of DRC-1339 died within 22 days. Bobwhite quail fed similar diets suffered some mortality at levels as low as 2.9 ppm, but most survived 10 times this dosage level for the 120-day test period. Application of the Kenaga “Index of Chronicity,” resulted in the conclusion that DRC-1339 was cumulatively toxic to birds.
Reproduction in coturnix was adversely affected by treatments at 10 ppm of DRC-1339 and above. Reproduction in pigeons was adversely affected by a treatment of 25 ppm. In coturnix, DRC-1339 caused an increased incidence of egg breakage and decreased both egg and live chick production. In pigeons, DRC-1339 caused an increase in the proportion of infertile eggs. Reproductive ability of first generation offspring was not affected when parent coturnix and pigeons were fed DRC-1339.
These data emphasize the need for care in the use of DRC-1339. The bait should be used only as registered and care exercised in storage and disposal of unused baits to avoid poisoning of nontarget species.
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References
Apostolou, A.: Comparative toxicity of the avicides 3-chloro-p-toluidine and 2-chloro-4-acetotoluidide in birds and mammals. Ph.D. Thesis.Univ. of California, Davis. 178pp (1969).
Apostolou, A., and S. A. Peoples: The development of tolerance of 3-chloro-p-toluidine in the rat. Proc. Soc. Exp. Biol. Med.134, 577 (1970).
Apostolou, A., and S. A. Peoples: Toxicity of the avicide 2-chloro-4-acetotoluidide in rats: A comparison with its nonacetylated form 3-chloro-p-toluidine. Toxicol. Appl. Pharmacol.18, 517 (1971).
Besser, J. F., W. C. Royall, Jr., and J. W. De Grazio: Baiting starlings with DRC-1339 at a cattle feedlot. J. Wildl. Manage.31, 48 (1967).
Borison, H. C., S. R. Snow, D. S. Longnecher and R. P. Smith: 3-Chloro-p-toluidine: Effects of lethal doses in rats and cats. Toxicol. Appl. Pharmacol.31, 403 (1975).
DeCino, T. J., D. J. Cunningham, and E. W. Schafer, Jr.: Toxicity of DRC-1339 to starlings. J. Wildl. Manage.30, 249 (1966).
Felsenstein, W. C., R. P. Smith, and R. E. Gosselin: Toxicological studies on the avicide 3-chloro-4-methylaniline. Toxicol. Appl. Pharmacol.28, 110 (1974).
Guarino, J. L., and E. W. Schafer, Jr.: Magpie reduction in an urban roost.U.S. Bur. Sport Fish. and Wildl., Spec. Sci. Rept.—Wildl. No. 104. 5pp (1967).
Kenaga, E. E.: Factors to be considered in the evaluation of the toxicity of pesticides to birds in their environment. In F. Coulston and F. Korte (Eds.): Environmental Quality and Safety. Academic Press, N.Y., N.Y. Vol. II, pp 166 (1973).
Larsen, K. H., and J. H. Dietrich: Reduction of a raven population on lambing grounds with DRC-1339. J. Wildl. Manage.34, 200 (1970).
Mull, R. L.: Comparative studies of acute and subacute toxicity of 3-chloro-p-toluidine. Effects of an acutely toxic dose in chickens on certain clinical biochemical parameters, and comparative studies of a renal aromaticN-deacylase. Ph.D. Thesis.Univ. California, Davis, 111pp (1971).
Mull, R. L., and S. N. Giri: Role of renal aromaticN-deacetylase in selective toxicity of avicide 3-chloro-p-toluidine in birds. Biochem. Biophys. Acta273, 222 (1972).
Mull, R. L., S. N. Giri, and S. A. Peoples: Effects of an acutely toxic dose of the avicide 3-chloro-p-toluidine in chickens. Toxicol. Appl. Pharmacol.22, 458 (1972).
Royall, W. C., Jr., T. C. DeCino, and J. F. Besser: Reduction of a starling population at a turkey farm. Poult. Sci.46, 1494 (1967).
Schafer, E. W., Jr.: The acute oral toxicity of 369 pesticidal, pharmaceutical, and other chemicals to wild birds. Toxicol. Appl. Pharmacol.21, 315 (1972).
Schafer, E. W., Jr. R. B. Brunton, and N. F. Lockyer: The effects of subacute and chronic exposure to 4-aminopyridine on reproduction in coturnix quail. Bull. Environ. Contam. Toxicol.13, 758 (1975).
Thompson, W. R.: Use of moving averages and interpolation to estimate median effective dose. Bact. Rev.11, 115 (1947).
Thompson, W. R. and C. S. Weil: On the construction of tables for moving average interpolation. Biometrics8, 51 (1952).
Waletzky, E., and S. Kantor: Controlling birds with haloalkyl nitrobenzamines. U.S. Patent 3,247,-060. 6pp (1966).
West, R. R.: Reduction of a winter starling population by baiting its preroosting areas. J. Wildl. Manage.32, 637 (1968).
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Schafer, E.W., Brunton, R.B., Cunningham, D.J. et al. The chronic toxicity of 3-chloro-4-methyl benzamine HCl to birds. Arch. Environ. Contam. Toxicol. 6, 241–248 (1977). https://doi.org/10.1007/BF02097765
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DOI: https://doi.org/10.1007/BF02097765