Abstract
A case of splenic hamartoma associated with thrombocytopenia is reported. A 70-year-old man was referred to our hospital because of carcinoma of the body of the pancreas. Hematological examination disclosed thrombocytopenia and elevated serum CA19-9 and Span-1 levels. In addition to typical findings of pancreatic carcinoma, a solid mass was observed in the spleen by imaging procedures. On ultrasonography, the splenic mass was well demarcated and slightly hypoechoic. Computed tomography demonstrated a homogeneous low-density mass 5 cm in diameter. On T1- and T2-weighted magnetic resonance images, the splenic mass was demonstrated as low intensity and high intensity, respectively. On selective angiography, the tumor was hypervascular. Distal pancreatectomy plus splenectomy was performed. Microscopically, the splenic tumor consisted of red pulp tissue and was diagnosed as splenic hamartoma.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Rokitansky K. Uber Splenoma. Lehrbuch der Pathol Anat Bd 1861;3.
Silverman ML, Livolsi VA. Splenic hamartoma. Am J Clin Pathol 1978;70:224–229.
Hisano S, Sumiyoshi A, Tanaka T, et al. Splenic hamartorna. Jpn J Cancer Clin 1973;19:1193–1198.
Kishikawa T, Numaguchi Y, Watanabe K, et al. Angiographic diagnosis of benign and malignant splenic tumors. Am J Roentgenol 1978;130:339–344.
Beham A, Hermann W, Venningerholz F, et al. Hamartoma of the spleen with haematological symptoms. Virchows Arch A Pathol Anat Histopathol 1989;414:535–539.
Iozzo RV, Haas JE, Chard RL. Symptomatic splenic hamartoma: A report of two cases and review of the literature. Pediatrics 1980;66:261–265.
Bhagwat AG, Datta DV, Mitra S, et al. Splenoma with portal hypertension. BMJ 1975;3:520.
Singh K, Subbramaiah A, Choudhary SR, et al. Splenic hamartoma with portal hypertension: A case report. Trop Gastroenterol 1992;13:155–159.
Videbaek A. Hypersplenism associated with harmartomas of the spleen. Acta Med Scand 1953;146:275–28O.
Morgenstern L, Cafferty MC, Rosenberg J. et al. Hamartoma of spleen. Arch Surg 1984;119:1291–1293.
Darden JW, Teeslink R, Parrish RA. Hamartoma of spleen, a manifestation of tuberous sclerosis. Ann Surg 1975;41:564–566.
Vere Nicoll JA. Splenic haematoma after spontaneous rupture of the spleen. Am J Surg 1968;116:117–119.
Ferguson ER, Sardi A, Beckman EN. Spontaneous rupture of splenic hamartoma. J La State Med Soc 1993;145:48–52.
Komaki S, Gombar DF. Angiographic demonstration of a calcified splenic hamartoma. Radiology 1976;121:77–78.
Ohta M, Tsutsumi Y, Tanaka Y. Splenic hamartoma. Acta Pathol Jpn 1986;36:471–480.
Ohtomo K, Fukuda H, Mori K, et al, CT and MR appearances of splenic hamartoma. J Comput Assist Tomogr 1992;16:425–428.
Graham JC Jr, Weidner WA, Vinik M. The angiographic features of organizing splenic hematoma. Am J Roentgenol 1969;107:430–433.
Havlik RJ, Touloukian RJ, Markowitz RI, et al. Partial splenectomy for symptomatic splenic hamartoma. J Pediatr Surg 1990;25:1273–1275.
Spalding RM, Jennings CV, Yam LT. Splenic hamartoma, Br J Radiol 1980;53:1197–1200.
Halevy A, Adam YG, Reif R, et al. Hamartoma of the spleen associated with thrombocytopenia mimicking gastric tumors. Int Surg 1982;67:462–463.
Teates CD, Seale DI, Allen MS. Hamartoma of the spleen. Am J Roentgenol 1972;116:419–422.
Zukerberg LR, Kaynor BL, Silverman ML, et al. Splenic hamartoma and capillary hemangioma are distinct entities: Immunohistochemical analysis of CD8 expression by endothelial cells. Hum Pathol 1991;22:1258–1261.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fujii, T., Obara, T., Shudo, R. et al. Splenic hamartoma associated with thrombocytopenia. J Gastroenterol 32, 114–118 (1997). https://doi.org/10.1007/BF01213307
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01213307