Abstract
We report herein the unusual case of a 60-year-old woman with an anaplastic thyroid carcinoma which produced granulocyte colony stimulating factor (G-CSF). She presented with large neck masses, respiratory difficulty, and a high fever. Laboratory examinations revealed marked leukocytosis of 43,200/mm3 with 85% granulocytes and an elevated G-CSF level of 67 pg/dl. Total thyroidectomy with bilateral node dissection and tracheostomy was performed, and a histological diagnosis of large-cell anaplastic thyroid carcinoma was confirmed. Immunohistochemical examination with a polyclonal antibody against G-CSF stained the tumor cells. Although the respiratory difficulty, fever, and marked granulocytosis subsequently improved, she died 1 month after undergoing surgery due to metastatic mediastinal disease.
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References
Bradley TR, Metcalf D (1966) The growth of mouse bone marrow cells in vitro. Aust J Biol Med Sci 44:287–300
Robinson WA (1974) Granulocytosis in neoplasia. Ann NY Acad Sci 230:212–218
Ohsawa N, Ueyama Y, Morita K, Kondo Y (1977) Heterotransplantation of human functioning tumors to nude mice. In: Nomura T, Ohsawa N, Tamaoki N, Fujisawa K (eds) Proceedings of the Second International Workshop on Nude Mice. University of Tokyo Press, pp 395–404
Asano S, Urabe A, Okabe T, Sato N, Kondo Y, Ueyama Y, Chiba S, Ohsawa N, Kosaka K (1977) Demonstration of granulopoeitic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood 49:845–851
Saeki T, Saeki S, Yokoyama H, Fukuda F, Sato R, Morooka C, Inoue S, Uesaka Y (1990) A case of colony stimulating factor (CSF) producing gastric cancer (in Japanese with English abstract) Gann No Rinsho (Jpn J Cancer Clin) 36:2469–2474
Saito K, Kuratomi Y, Yamamoto K, Saito T, Kuzuya T, Soshida S, Moriyama S, Takahashi A (1981) Primary squamous cell carcinoma of the thyroid associated with marked leukocytosis and hypercalcemia. Cancer 48:2080–2083
Okabe T, Nomura H, Oshawa N (1982) Establishment and characterization of a human colony-stimulating factor-producing cell line from a squamous cell carcinoma of the thyroid gland. J Natl Cancer Inst 69:1235–1243
Hirayu S, Izumi M, Sato K, Tomita I, Tomonaga M, Nagataki S (1984) A case of thyroid cancer with CSF activity (in Japanese). Horumon To Rinshop (Clin Endocrinol) 32:143–144
Ishihara T, Hino M, Waseda N, Ikekubo K, Mori T (1986) A case of squamous cell carcinoma of thyroid producing GM-CSF (in Japanese). Horumon To Rinsho (Clin Endocrinol) 34:169–171
Takaoka K, Inoue S, Fujiya S, Kishi F, Abe S, Kawakami Y, Kobayashi M, Ishikawa N, Kikuchi Y (1986) Report on a case of colony stimulating factor (CSF) producing anaplastic thyroid carcinoma (in Japanese). Nippon Naika Gakkai Zasshi (Jpn J Intern Med) 75:69–74
Inoue D, Sugawa S, Hosoda K, Miyamoto M, Takahashi T, Mori T, Imura H, Kitamura N, Yamamoto I (1987) Establishment of the anaplastic thyroid carcinoma cell line and the estimation of the products (in Japanese). Nippon Naibunpi Gakkai Zasshi (Folia Endocrinol Jpn) 63:1051 (Abstract)
Kobayashi H, Endo K, Nishimura K, Kasagi K, Yamamoto I, Konishi J, Abe M, Shimizu Y (1989) A case report of a thyroid papillary cancer manifested leucocytosis and hypercalcemia after radiotherapy for bone metastasis (in Japanese with English abstract). Gann No Rinshou (Jpn J Cancer Clin) 35:55–62
Demeter JG, De Jong SA, Lawrence AM, Paloyan E (1991) Anaplastic thyroid carcinoma: risk factors and outcome. Surgery 110:956–963
Hsu SM, Raine L, Fanger H (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques. A comparison between ABC and unlabeled (PAP) procedures. J Histochem Cytochem 29:577–580
Yoshiwara K, Fukuyama K, Okamura T, Watanabe S, Nishihara H, Sumita I, Hanada M (1986) A case of autopsy of the CSF (colony-stimulating factor) producing lung cancer (in Japanese with English abstract). Gann No Rinshou (Jpn J Cancer Clin) 32:805–809
Sato K, Fujii Y, Ono M, Nomura H, Shizume K (1987) Production of interleukin 1α-like factor and colony-stimulating factor by a squamous cell carcinoma of the thyroid (T3M-5) derived from a patient with hypercalcemia and leukocytosis. Cancer Res 47:6474–6480
Takeeda T, Ichiyanagi A, Sano K, Yoshida J, Tsutsumi Y, Miyaji T (1990) A case of gallbladder cancer producing granulocyte-colony-stimulating factor. Gastroenterologia Japonica 25:762–767
Brooks JR, Starnes HF, Brooks DC, Pelkey JN (1988) Surgical therapy for thyroid carcinoma: a review of 1249 solitary thyroid nodules. Surgery 104:940–946
Nishiyama RH, Dunn EL, Thompson NW (1972) Anaplastic spindle-cell and giant cell tumors of the thyroid gland. Cancer 30:113–127
Wychulis AR, Beahrs OH, Woolner LB (1965) Papillary carcinoma associated with anaplastic carcinoma in the thyroid gland. Surg Gynecol Obstet 120:28–34
Harada T, Ito K, Shimaoka K, Hosoda Y, Yakumaru K (1977) Fatal thyroid carcinoma: anaplastic transformation of adenocarcinoma. Cancer 39:2588–2596
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Iwasa, K., Noguchi, M., Mori, K. et al. Anaplastic thyroid carcinoma producing the granulocyte colony stimulating factor (G-CSF): Report of a case. Surg Today 25, 158–160 (1995). https://doi.org/10.1007/BF00311090
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DOI: https://doi.org/10.1007/BF00311090