Abstract
Ultrastructural changes in the skin lesions of pemphigoid vegetans were observed by transmission electron microscopy. Two significant changes were recognized at the vegetating site: (1) The basal lamina was sometimes interrupted and detached from the basal cells, protruding into the dermis to form folds. In the basal cells, hemidesmosomes were not decreased in number but tonofilament bundles were fewer than normal. Occasionally, basal cell processes extended beyond the basal lamina through its gap. These features resembled the epidermal growth factor-induced morphological changes of cultured skin. It was suspected that the abnormal attachment of the basal lamina to the basal cell was associated with keratinocyte proliferation. (2) Mast cells were encountered in the epidermis abutting on the basal lamina. It is uncommon to find mast cells in the epidermis. Mast cells in the epidermis were reported at the erythematous regions which were adjacent to the bullae of bullous pemphigoid, and were thought to have an important role in forming blisters. It was suggested that early changes in blister formation occur at the vegetating site.
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References
Winkelman RK, Su WPD (1979) Pemphigoid vegetans. Arch Dermatol 115:446–448
Kuokkanen K, Helin H (1981) Pemphigoid vegetans: report of a case. Arch Dermatol 117:56–57
Al-Najjar A, Reilly GD, Bleehen SS (1984) Pemphigoid vegetans: a case report. Acta Derm Venereol (Stockh) 64:450–452
Ogasawara M, Matsuda S, Nishioka K, Asagami C (1994) Pemphigoid vegetans. J Am Acad Dermatol 30:649–650
Galli SJ, Dvorak AM, Hammond E, Morgan E, Galli AS, Dvorak HF (1981) Guinea pig basophil morphology in vitro: I. Ultrastructure of uropod-bearing (motile) basophils and modulation of motile structures by serum and substrate effects. J Immunol 126:1066–1074
Kitajima Y, Hirako Y, Owaribe K, Mori S, Yaoita H (1994) Antibody-binding to the 180-kD bullous pemphigoid antigens at the lateral cell surface causes their internalization and inhibits their assembly at the basal cell surface in cultured keratinocytes. J Dermatol 21:838–846
Akimoto Y, Obinata A, Endo H, Hirano H (1984) Epidermal growth factor (EGF)-induced morpholgical changes in the basement membrane of chick embryonic skin, an electron-microscopic study. Cell Tissue Res 254:481–485
Hashimoto K, Higashiyama M, Iwatsuki K, Yoshikawa K (1991) Involvement of increase of EGF receptor and TGF-α in epidermal hyperplasia of pemphigus vegetans. J Invest Dermatol 96:553
Eady RAJ, Cowen T, Marshall TF, Plummer V, Greaves MW (1979) Mast cell population density, blood vessel density and histamine content in normal human skin. Br J Dermatol 100:623–633
Dvorak AM, Mihm MC Jr, Osage JE, Kwan TH, Austen KF, Wintroub BU (1982) Bullous pemphigoid, an ultrastructural study of the inflammatory response: eosinophil, basophil and mast cell granule changes in multiple biopsies from one patient. J Invest Dermatol 78:91–101
Wintroub BU, Mihm MC Jr, Goetzl EJ, Soter NA, Austen KF (1980) Morphologic and functional evidence for release of mastcell products in bullous pemphigoid. N Engl J Med 294:417–421
Dubertret L, Bertaux B, Fosse M, Touraine R (1980) Cellular events leading to blister formation in bullous pemphigoid. Br J Dermatol 104:615–624
Yoshioka J (1981) Studies on pemphigoid: II. Histopathological and electron microscopic investigation. Hifu 23:55–75
Kimura I, Takahashi K (1984) A role of basophil-mast cell and cosinophil in allergic disease. Prog Med 4:2429–2437
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Ogasawara, M. An ultrastructural study of pemphigoid vegetans, characterizing the possible mechanism of vegetation. Med Electron Microsc 30, 48–54 (1997). https://doi.org/10.1007/BF01458352
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DOI: https://doi.org/10.1007/BF01458352