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A super long-acting LH-RH analogue induces regression of hypothalamic hamartoma associated with precocious puberty

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Summary

We treated a 1-year-old female with a hypothalamic hamartoma and precocious puberty with leuprolide acetate depot, a super long-acting hormone-releasing hormone analogue (Tap-144-SR; [D-Leu6-[des-Gly10-NH2]-LH-RH ethylamide acetate). The infant's major symptoms were genital bleeding and gynaecomastia. The LH-RH analogue (30 μg/kg) was injected subcutaneously once every 4 weeks. Clinical and laboratory manifestations of precocious puberty showed marked improvement. A follow-up after 16 months of treatment, the size of the tumour decreased significantly and remained unchanged for 2 years of further follow-up. To the best of our knowledge, this is the first hypothalamic hamartoma case in whom a decrease of tumour size under treatment with LH-RH analogue has been documented. But, because diagnosis of hamartoma is only based on neuroradiological and not on histological examinations, the possibility of a gangliocytoma cannot be excluded with certainty.

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Author notes

  1. K. Harada

    Present address: Department of Neurosurgery, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan

Authors and Affiliations

  1. Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan

    K. Harada, J. Yoshida, T. Wakabayashi, H. Okabe & K. Sugita

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  1. K. Harada
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  2. J. Yoshida
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  3. T. Wakabayashi
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  4. H. Okabe
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Harada, K., Yoshida, J., Wakabayashi, T. et al. A super long-acting LH-RH analogue induces regression of hypothalamic hamartoma associated with precocious puberty. Acta neurochir 137, 102–105 (1995). https://doi.org/10.1007/BF02188791

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