Summary
One group of cats had an acrylic screw implanted into the adqueduct of Sylvius, while the other group of animals received a solution of kaolin into the cisterna magna. Three weeks later the dye phenolsulphonphthalein was instilled into the lateral ventricle to ascertain communication between CSF compartments, and thereafter the brain was perfused with formalin. As shown by planimetry of brain ventricles both groups of experimental animals developed hydrocephalus, i.e., coronal surface of brain ventricles was about 10 times larger in kaolin and about 3 times in aqueductal screw experiments than in the controls, respectively.
In aqueductal screw experiments communication of CSF between lateral ventricle and subarachnoid spaces was not blocked but only restricted, i.e., an aqueductal stenosis was produced. In kaolin experiments communication of CSF between lateral ventricles and spinal subarachnoid space was blocked by thick meningeal adhesions in the upper cervical region, while the central spinal canal was dilated (hydromyelia) with enhanced CSF communication between it and the lumbar subarachnoid space.
We assume that during systolic expansion of brain the CSF is displaced from the cranial cavity toward the spinal subarachnoid space which accommodates an additional volume of CSF primarily due to compliance of the spinal durai sac, while during diastole CSF recoils in the opposite direction. Thus, in case of aqueductal stenosis the undisplaced volume of CSF from the ventricles can be accommodated due to diminution of cerebral blood volume and brain parenchyma so that hydrocephalus develops over time. Since the cervical subarachnoid space is blocked in kaolin experiments the systolic brain expansion forces CSF from basal cisterns via the fourth ventricle into the aqueduct and central canal with consequent development of hydrocephalus and hydromyelia.
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References
Becker DP, Wilson JA, Watson GW (1972) Spinal cord central canal: response to experimental hydrocephalus and canal occlusion. J Neurosurg 36: 416–424
Bering EA (1955) Choroid plexus and arterial pulsation of the choroid plexus as a cerebrospinal fluid pump. Arch Neurol Psychiatr 73: 165–172
Bulat M (1993) Dynamics and statics of the cerebrospinal fluid: the classical and new hypothesis. In: Avezaat CJJet al (eds) Intracranial pressure VIII. Springer, Berlin Heidelberg New York Tokyo, pp 726–730
Bulat M, Zivković B (1978) Neurochemical study of the cerebrospinal fluid. In: Marks N, Rodnight R (eds) Research methods in neurochemistry, Vol 4. Plenum. New York, pp 57–89
Bulat M, Miše B, Klarica M (1995) Destructive force of the cerebrospinal fluid in acute hydrocephalus: a new hypothesis. In: Paoletti Ret al (eds) Abstract book, First Europ Cong Pharmacol. Pharmacol Res 31 [Suppl] 294
Chai WX (1995) Long-term results of fourth ventriculo-cister-nostomy in complex versus simplex atresias of the fourth ventricle outlets. Acta Neurochir (Wien) 134: 27–34
Conner ES, Foley L, Black PMcL (1984) Experimental normal-pressure hydrocephalus is accompanied by increased transmantle pressure. J Neurosurg 61: 322–327
Davson H, Welch K, Segal MB (1987) Physiology and pathophysiology of the cerebrospinal fluid. Churchill Living-stone, Edinburgh
Di Rocco C (1984) Hydrocephalus and cerebrospinal fluid pulses. In: Shapiro Ket al (eds) Hydrocephalus. Raven, New York, pp 231–249
Du Boulay G, Shah SH, Currie JC, Logue V (1974) The mechanism of hydromyelia in Chiari type 1 malformations. Br J Radiol 47: 579–587
Eisenberg HM, McLennan JE, Welch K (1974) Ventricular perfusion in cats with kaolin-induced hydrocephalus. J Neurosurg 41: 20–28
Enzmann DR, Pelc NJ (1991) Normal flow patterns of intracranial and spinal cerebrospinal fluid defined with phase-contrast cine MR imaging. Radiol 178: 467–474
Feinberg DA, Mark AS (1987) Human brain motion and cerebrospinal fluid circulation demonstrated with MR velocity imaging. Radiology 163: 793–799
Fischer EG, Welch K, Shillito J (1977) Syringomyelia following lumboureteral shunting for communicating hydrocephalus. J Neurosurg 47: 96–100
Foltz EL (1984) Hydrocephalus and CSF pulsatility: clinical and laboratory studies. In: Shapiro Ket al (eds) Hydrocephalus. Raven, New York, pp 337–362
Giordana MT, Bradac GB, Pagni CA, Marino S, Attanasio A (1995) Primary diffuse leptomeningeal gliomatosis with anaplastic features. Acta Neurochir (Wien) 132: 154–159
Gonzalez-Darder J, Barbera J, Cerda-Nicolas M, Segura D, Broseta J, Barcia-Salorio JL (1984) Sequential morphological and functional changes in kaolin-induced hydrocephalus. J Neurosurg 61: 918–924
Hochwald G (1984) Animal model of hydrocephalus. In: Shapiro Ket al (eds) Hydrocephalus. Raven, New York, pp 199–213
Hochwald GM, Sahar A, Sadik AR, Ranshoff J (1969) Cerebrospinal fluid production and histological observations in animals with experimental obstructive hydrocephalus. Exp Neurol 25: 190–199
Klarica M, Gmajnički B, Oreškivić D, Bulat M (1993) Osmotic force of the CSF and intracranial pressure in health and disease. In: Avezaat CJJet al (eds) Intracranial pressure VIII. Springer, Berlin Heidelberg New York Tokyo, pp 735–737
Martins AN, Wiley JK, Myers PW (1972) Dynamics of the cerebrospinal fluid and spinal dura mater. J Neurol Neurosurg Psychiatry 35: 468–473
McComb JG (1989) Cerebrospinal fluid formation and absorption. In: McLaurin RLet al (eds) Pediatric neurosurgery, 2nd Ed. Saunders, Philadelphia, 1989, pp 159–169
McCormick JM, Yamada K, Rekate HL, Miyake H (1992) Time course of intraventricular pressure change in a canine model of hydrocephalus: its relationship to sagittal sinus elastance. Pediatr Neurosurg 18: 127–133
Milhorat TH (1972) Hydrocephalus and the cerebrospinal fluid. Williams and Wilkins, Baltimore
Milhorat TH (1989) Circulation of the cerebrospinal fluid. In: McLaurin RLet al (eds) Pediatric neurosurgery, 2nd Ed. Saunders, Philadelphia, pp 170–179
Milhorat TH, Clark RG (1970) Some observations on the circulation of phenolsulphonphthalein in cerebrospinal fluid: normal flow and the flow in hydrocephalus. J Neurosurg 32: 522–528
Orešković D, Bulat M (1993) Hydrostatic force in regulation of CSF volume. In: Avezaat CJJet al (eds) Intracranial pressure VIII. Springer, Berlin Heidelberg New York Tokyo, pp 731–734
Pappenheimer JR, Heisey SR, Jordan EF (1961) Active transport of Diodrast and phenolsulphonphthalein from cerebrospinal fluid to blood. Am J Physiol 200: 1–10
Pollay M (1984) Research into human hydrocephalus: a review. In: Shapiro Ket al (eds) Hydrocephalus. Raven, New York, pp 301–314
Sato O, Ohya M, Nojiri K, Tsugane R (1984) Microcirculatory changes in experimental hydrocephalus: morphological and physiological studies. In: Shapiro Ket al (eds) Hydrocephalus. Raven, New York, pp 215–230
Sgouros S, Williams B (1995) A critical appraisal of drainage in syringomyelia. J Neurosurg 82: 1–10
Shapiro K, Kohn IJ, Takei F, Zee C (1987) Progressive ventricular enlargement in cats in the absence of transmantle pressure gradients. J Neurosurg 67: 88–92
Snider RS, Niemer WT (1961) A stereotaxic atlas of the cat brain. The University of Chicago Press, Chicago
Vladić A (1995) Dynamics of3H-inulin distribution in the cerebrospinal fluid. Ph D Thesis (in Croatian), University of Zagreb
Vladić A, Bulat M (1988) Distribution of3H-inulin by CSF pulsation and body activity into various compartments of the CSF. Iugoslav Physiol Pharmacol Acta 24: 489–491
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Miše, B., Klarica, M., Seiwerth, S. et al. Experimental hydrocephalus and hydromyelia: A new insight in mechanism of their development. Acta neurochir 138, 862–869 (1996). https://doi.org/10.1007/BF01411265
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DOI: https://doi.org/10.1007/BF01411265