Summary
Prostacyclin (PGI2), a strong vasodilator of cerebral vessels and potent inhibitor of platelet aggregation, was infused intravenously into seven cats after induction of prolonged vasospasm by hourly application of oxyhaemoglobin solution into the subarachnoid space round the basilar artery. PGI2, at a concentration of 50 ng/kg/min, was effective in releasing the vasospasm in the seven cats. It did not produce significant hypotension. This report gives our results and the probable mechanism of action of PGI, in cerebral vasospasm.
Similar content being viewed by others
References
Anderson, R. G. G., Cyclic AMP and calcium ions in mechanical and metabolic responses of smooth muscles: Influences of some hormones and drugs. Acta Physiol. Scand.87 (Suppl. 382) (1972), 1–59.
Boullin, D. J., Bunting, S., Blaso, W. P., Hunt, T. M., Moncada, S., Responses of human and baboon arteries to prostaglandin endoperoxides and biologically generated and synthetic prostacyclin: their relevance to cerebral arterial spasm in man. Brit. J. Clin. Pharm.7 (1979), 139–147.
Chapleau, C. E., White, R. P., Effects of prostacyclin on the canine isolated basilar artery. Prostaglandins17 (1979), 573–580.
Endo, S., Suzuki, J., Experimental cerebral vasospasm after subarachnoid hemorrhage. Development and degree of vasospasm. Stroke8 (1977), 702–707.
Fitzgerald, G. A., Friedman, L. A., Miyamori, I., O'Grady, J., Lewis, P. J., A double blind placebo controlled crossover study of prostacyclin in man. Life Sciences25 (1979), 665–672.
Flamm, E. S., Viau, A. T., Ransohoff, J., Naftchi, N. E., Experimental alterations in cyclic adenosine monophosphate concentrations in the cat basilar artery. Neurology (Minneap.)26 (1976), 664–666.
Gorman, F. F., Bunting, S., Miller, O. V., Modulation of human platelet adenylate cyclase by prostacyclin (PGX). Prostaglandins13 (1977), 377–388.
Gryglewski, R. J., Szczeklik, A., Nizankowski, R., Antiplatelet action of intravenous infusion of prostacyclin in man. Thrombosis Research13 (1978), 153–163.
Herman, A. G., Moncada, S., Vane, J. R., Formation of prostacyclin (PGI2) by different layers of the arterial wall. Arch. Int. Pharmacodyn. Ther.227 (1976), 162–163.
Jarman, D. A., Du Boulay, G. H., Kendall, B., Boullin, D. J., Responses of baboon cerebral and extracerebral arteries to prostacyclin and prostaglandin endoperoxide in vitro and in vivo. J. Neurol. Neurosurg. Psychiat.42 (1979), 677–686.
Longmore, D. B., Hoyle, P. M., Gregory, A., Bennet, J., Smith, M. A., Osivand, T., Jones, W. A., Prostacyclin administration during cardiopulmonary bypass in man. Lancet, April11 (1981), 800–803.
Miller, O. V., Aiken, J. W., Hemker, D. P., Shebuski, R. J., Gorman, R. R., Prostacyclin stimulation of dog arterial cyclic AMP levels. Prostaglandins18 (1979), 915–925.
Moncada, S., Gryglewski, R. J., Bunting, S., Vane, J. R., An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature263 (1976), 663–665.
Moncada, S., Vane, J. R., The role of prostacyclin in vascular tissue. Fed. Proc.38 (1979), 66–71.
Norwood, C. W., A review of recent advances in vascular muscle pharmacology. Surg. Neurol.7 (1977), 91–94.
Okada, H., Endo, S., Kamiyama, K., Suzuki, J., Oxyhemoglobin induced cerebral vasospasm and sequential changes of vascular ultrastructure. Neurol. Med. Chir. (Tokyo)20 (1980), 573–582 (English abstract).
Peterson, E. W., Leblanc, R., A theory of the mechanism of cerebral vasospasm and its reversal. The role of calcium and cyclic AMP. Le Journal Canadien des Sciences Neurologiques3 (1976), 223–226.
Sonobe, M., Suzuki, J., Vasospasmogenic substance produced following subarachnoid hemorrhage, and its fate. Acta neurochir. (Wien)44 (1978), 97–106.
White, R. P., Multiplex origins of vasoconstriction. In: Cerebral arterial spasm. Proceedings of the second international workshop, pp. 50–56 (Wilkins, R. H., ed.). Baltimore: Williams and Wilkins. 1980.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Quintana, L., Konda, R., Ishibashi, Y. et al. The effect of prostacyclin on cerebral vasospasm an experimental study. Acta neurochir 62, 187–193 (1982). https://doi.org/10.1007/BF01403623
Issue Date:
DOI: https://doi.org/10.1007/BF01403623