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ev22, a new endogenous avian leukosis virus locus found in chickens with spontaneous autoimmune thyroiditis

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Summary

Chickens of the Obese strain (OS) develop a hereditary spontaneous autoimmune thyroiditis (SAT) which closely resembles human Hashimoto's disease. Analysis of the endogenous viruses harboured by these animals revealed a new endogenous virus (ev22) detected as a 5.5kb Sac I fragment.

Crossbreeding experiments showed thatev22 is vertically transmitted as an autosomal trait not associated with major histocompatibility (MHC) alleles. Preliminary experiments indicate thatev22 does not necessarily cause SAT, however, it may have a modulatory role in the development of the disease.

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Authors and Affiliations

  1. Ludwig Institute for Cancer Research, Inselspital, Bern, Switzerland

    A. Ziemiecki & R. G. Mueller

  2. Institute for General and Experimental Pathology, University of Innsbruck, Innsbruck, Austria

    G. Krömer, K. Hàla & G. Wick

Authors
  1. A. Ziemiecki
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  2. G. Krömer
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  3. R. G. Mueller
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  4. K. Hàla
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  5. G. Wick
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Ziemiecki, A., Krömer, G., Mueller, R.G. et al. ev22, a new endogenous avian leukosis virus locus found in chickens with spontaneous autoimmune thyroiditis. Archives of Virology 100, 267–271 (1988). https://doi.org/10.1007/BF01487689

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  • DOI: https://doi.org/10.1007/BF01487689

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