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The role of the immune system in establishment of herpes simplex virus latency — studies using CD4+ T-cell depleted mice

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Summary

The immunological mechanisms involved in establishment of herpes simplex virus (HSV) latency were studied in normal and CD4+ T-cell depleted C57BL/6J mice following intravaginal infection. During transition from acute to latent ganglionic infection two consecutive processes were observed: first, clearance of infectious virus from the ganglia, and second, reduction of the number of infected ganglia.

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References

  1. Bauer D, Schneweis KE (1988) Does interferon mediate herpes simplex virus latency? The effect of anti-interferon in the mouse model. Joint meeting of the Sektion Virologie der Deutschen Gesellschaft für Hygiene und Mikrobiologie and The Virus Group of the Society for General Microbiology, September 15–17, Hamburg 1988

  2. Bonneau RH, Jennings SR (1989) Modulation of acute and latent herpes simplex virus infection in C57BL/6 mice by adoptive transfer of immune lymphocytes with cytolytic activity. J Virol 63: 1480–1484

    Google Scholar 

  3. Bonneau RH, Jennings SR (1990) Herpes simplex virus-specific cytolytic T lymphocytes restricted to a normally low responder H-2 allele are protective in vivo. Virology 174: 599–604

    Google Scholar 

  4. Cobbold SP, Jayasuriya A, Nash A, Prospero TD, Waldmann H (1984) Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 312: 548–551

    Google Scholar 

  5. Eis AM, Schneweis KE (1986) Pathogenesis of genital herpes simplex virus infection in mice. IV. Quantitative aspects of viral latency. Med Microbiol Immunol 175: 281–292

    Google Scholar 

  6. Eis-Hübinger AM, Mohr K, Schneweis KE (1991) Different mechanisms of protection by monoclonal and polyclonal antibodies during the course of herpes simplex virus infection. Intervirology 32: 351–360

    Google Scholar 

  7. Eis-Hübinger AM, Friedrich A, Schneweis KE (1992) Herpes simplex virus-specific hybridoma cells cannot be persistently infected with this virus. Intervirology 34: 13–22

    Google Scholar 

  8. Eis-Hübinger AM, Schmidt DS, Schneweis KE (1993) Anti-glycoprotein B monoclonal antibody protects T cell depleted mice against herpes simplex virus infection by inhibition of virus replication at the inoculated mucous membranes. J Gen Virol 74: 379–385

    Google Scholar 

  9. Erlich KS, Dix RD, Mills J (1987) Prevention and treatment of experimental herpes simplex virus encephalitis with human immune serum globulin. Antimicrob Agents Chemother 31: 1006–1009

    Google Scholar 

  10. Hampl W, Conrad S, Kleinschmidt AK (1991) Herpes simplex virus type 1 long-term persistence, latency, and reactivation in infected Burkitt lymphoma cells. Arch Virol 117: 251–267

    Google Scholar 

  11. Joly E, Mucke L, Oldstone MBA (1991) Viral persistence in neurons explained by lack of major histocompatibility class I expression. Science 253: 1283–1285

    Google Scholar 

  12. Kapoor AK, Nash AA, Wildy P (1982) Pathogenesis of herpes simplex virus in B cell-suppressed mice: the relative roles of cell-mediated and humoral immunity. J Gen Virol 61: 127–131

    Google Scholar 

  13. Kapoor AK, Nash AA, Wildy P, Phelan J, McLean CS, Field HJ (1982) Pathogenesis of herpes simplex virus in congenitally athymic mice: the relative roles of cell-mediated and humoral immunity. J Gen Virol 60: 225–233

    Google Scholar 

  14. Kino Y, Hayashi Y, Hayashida I, Mori R (1982) Dissemination of herpes simplex virus in nude mice after intracutaneous inoculation and effect of antibody on the course of infection. J Gen Virol 63: 475–479

    Google Scholar 

  15. Klein RJ (1980) Effect of immune serum on the establishment of herpes simplex virus infection in trigeminal ganglia of hairless mice. J Gen Virol 49: 401–405

    Google Scholar 

  16. Kumano Y, Yamamoto M, Mori R (1987) Protection against herpes simplex virus infection in mice by recombinant murine interferon-γ in combination with antibody. Antiviral Res 7: 289–301

    Google Scholar 

  17. Levine B, Hardwick JM, Trapp BD, Crawford TO, Bollinger RC, Griffin DE (1991) Antibody-mediated clearance of alphavirus infection from neurons. Science 254: 856–860

    Google Scholar 

  18. Mauerhoff T, Pujol-Borrell R, Mirakian R, Bottazzo GF (1988) Differential expression and regulation of major histocompatibility complex (MHC) products in neural and glial cells of the human fetal brain. J Neuroimmunol 18: 271–289

    Google Scholar 

  19. McKendall RR, Klassen T, Baringer JR (1979) Host defenses in herpes simplex infections of the nervous system: effect of antibody on disease and viral spread. Infect Immun 23: 305–311

    Google Scholar 

  20. McKendall RR (1985) IgG-mediated viral clearance in experimental infection with herpes simplex virus type 1: role for neutralization and Fc-dependent functions but not C′ cytolysis and C5 chemotaxis. J Infect Dis 151: 464–470

    Google Scholar 

  21. Momburg F, Koch N, Möller P, Moldenhauer G, Hämmerling GJ (1986) In vivo induction of H-2K/D antigens by recombinant interferon-γ. Eur J Immunol 16: 551–557

    Google Scholar 

  22. Nash AA, Jayasuriya A, Phelan J, Cobbold SP, Waldmann H, Prospero T (1987) Different roles for L3T4+ and Lyt 2+ T cll subsets in the control of an acute herpes simplex virus infection of the skin and nervous system. J Gen Virol 68: 825–833

    Google Scholar 

  23. Oakes JE, Rector JT, Lausch RN (1984) Lyt-1+ T cells participate in recovery from ocular herpes simplex virus type 1 infection. Invest Ophthalmol Vis Sci 25: 188–194

    Google Scholar 

  24. Openshaw H, Asher LVS, Wohlenberg C, Sekizawa T, Notkins AL (1979) Acute and latent infection of sensory ganglia with herpes simplex virus: immune control and virus reactivation. J Gen Virol 44: 205–215

    Google Scholar 

  25. Reed JL, Muench H (1938) A simple method for estimating fifty percent endpoints. Am J Hyg 27: 493–497

    Google Scholar 

  26. Schneweis KE, Brado M, Ebers B, Friedrich A, Olbrich M, Schüler W (1988) Immunological mechanisms giving rise to latency of herpes simplex virus in the spinal ganglia of the mouse. Med Microbiol Immunol 177: 1–8

    Google Scholar 

  27. Sekizawa T, Openshaw H, Wohlenberg C, Notkins AL (1980) Latency of herpes simplex virus in absence of neutralizing antibody: model for reactivation. Science 210: 1026–1028

    Google Scholar 

  28. Shimeld C, Hill TJ, Blyth WA, Easty DL (1990) Passive immunization protects the mouse eye from damage after herpes simplex virus infection by limiting spread of virus in the nervous system. J Gen Virol 71: 681–687

    Google Scholar 

  29. Simmons A, Nash AA (1987) Effect of B cell suppression on primary infection and reinfection of mice with herpes simplex virus. J Infect Dis 155: 649–654

    Google Scholar 

  30. Simmons A, Tscharke DC (1992) Anti-CD 8 impairs clearance of herpes simplex virus from the nervous system: implications for the fate of virally infected neurons. J Exp Med 175: 1337–1344

    Google Scholar 

  31. Sokawa Y, Ando T, Ishihara Y (1980) Induction of 2′,5′-oligoadenylate synthetase and interferon in mouse trigeminal ganglia infected with herpes simplex virus. Infect Immun 28: 719–723

    Google Scholar 

  32. Speck PG, Simmons A (1992) Synchronous appearance of antigen-positive and latently infected neurons in spinal ganglia of mice infected with a virulent strain of herpes simplex virus. J Gen Virol 73: 1281–1285

    Google Scholar 

  33. Walz MA, Yamamoto H, Notkins AL (1976) Immunological response restricts number of cells in sensory ganglia infected with herpes simplex virus. Nature 264: 554–556

    Google Scholar 

  34. Yamada M, Arao Y, Hantano A, Uno F, Nii S (1988) Effect of recombinant mouse interferon-β on acute and latent herpes simplex infection in mice. Arch Virol 99: 101–109

    Google Scholar 

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Authors and Affiliations

  1. Institute of Medical Microbiology and Immunology, University of Bonn, Bonn, Federal Republic of Germany

    Daniela Susi Schmidt, Anna Maria Eis-Hübinger & K. E. Schneweis

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  1. Daniela Susi Schmidt
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  2. Anna Maria Eis-Hübinger
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  3. K. E. Schneweis
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Schmidt, D.S., Eis-Hübinger, A.M. & Schneweis, K.E. The role of the immune system in establishment of herpes simplex virus latency — studies using CD4+ T-cell depleted mice. Archives of Virology 133, 179–187 (1993). https://doi.org/10.1007/BF01309753

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  • DOI: https://doi.org/10.1007/BF01309753

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