Summary
An in vitro herpes simplex virus type 1 (HSV-1) latency model was established, using trigeminal ganglia from latently infected mice. When heat-treated at 43 °C for 3 h, reactivation followed in 76.6% of the cultures, while reactivation was not observed in non-heat-treated controls.
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References
Cushing H (1905) Surgical aspects of major neuralgia of trigeminal nerve; a report of twenty cases of operations on gasserian ganglion with anatomic and physiologic notes on consequences of its removal. JAMA 44: 920–929
Epstein NN (1941) Herpes simplex following artificial fever therapy. JAMA 117: 1327–1330
Friedenwald JS (1923) Studies in the virus of herpes simplex. Arch Ophthalmol 52: 105–131
Goodpasture EW (1929) Herpetic infection, with especial reference to involvement of the nervous system. Medicine 8: 223–243
Green M, Knesek J, Dunkel E, SeGall G (1987) Localization of3H-thymidine-labeled HSV-1 in latently infected rabbit trigeminal ganglion cells. Invest Ophthalmol Vis Sci 28: 394–397
Hill TJ, Blyth WA, Harbour DA (1977) Trauma to the skin causes recurrence of herpes simplex in the mouse. J Gen Virol 39: 21–28
Nesburn AB (1976) The effect of trigeminal nerve and ganglion manupulation on recurrence of ocular herpes simplex in rabbits. Invest Ophthalmol 15: 726–731
Nesburn AB, Cook ML, Stevens JG (1972) Latent herpes simplex infection: isolation from rabbit trigeminal ganglia between episodes of recurrent ocular infection. Arch Ophthalmol 88: 412–417
Sawtell NM, Thompson RL (1992) Rapid in vivo reactivation of herpes simplex virus in latently infected murine ganglionic neurons after transient hyperthermia. J Virol 66: 2150–2156
Shimeld C, Hill TJ, Blyth WA, Easty DL (1990) Reactivation of latent infection and induction of recurrent herpetic eye disease in mice. J Gen Virol 71: 397–404
Shimizu F, Monma Y, Sekizawa T, Kamiyama K (1989) Establishment of latent ganglionic infection with herpes simplex virus via maxillary gingiva and viral reactivation in vivo after trauma. J Dent Res 68: 472–475
Steiner I, Spivack JG, Deshmane SL, Ace Cl, Preston CM, Fraser NW (1990) A herpes simplex virus type 1 mutant containing a nontransinducing Vmw65 protein establishes latent infection in vivo in the absence of viral replication and reactivates efficiently from explanted trigeminal ganglia. J Virol 64: 1630–1638
Theobald S (1916) Herpes corneae “febrilis”. NY Med J 104: 247–248
Warren SL, Carpenter CM, Boak RA (1940) Symptomatic herpes, a sequela of artificially induced fever. J Exp Med 71: 155–168
Wigdahl BL, Scheck AC, de Clercq Ed, Rapp F (1983) High efficiency latency and activation of herpes simplex virus in human cells. Science 217: 1145–1146
Wilcox CL, Johnson EMJ (1987) Nerve growth factor deprivation results in the reactivation of latent herpes simplex virus in vitro. J Virol 61: 2311–2315
Wilcox CL, Smith RL, Freed CR, Johnson EMJ (1990) Nerve growth factor-dependence of herpes simplex virus latency in peripheral sympathetic and sensory neurons in vitro. J Neurosci 10: 1268–1275
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Moriya, A., Yoshiki, A., Kita, M. et al. Heat shock-induced reactivation of herpes simplex virus type 1 in latently infected mouse trigeminal ganglion cells in dissociated culture. Archives of Virology 135, 419–425 (1994). https://doi.org/10.1007/BF01310025
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DOI: https://doi.org/10.1007/BF01310025