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Characterization of a nonvirulent variant of lymphocytic choriomeningitis virus

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Summary

A cold-adapted, nonvirulent variant of the Armstrong strain of lymphocytic choriomeningitis virus was isolated from infected L929 cells maintained at 25° C. This variant, designated P17, was capable of replicating in the central nervous system of mice without causing disease and conferring immunity to back challenge with the parental strain.

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Author notes

  1. P. R. Brayton

    Present address: Departments of Neurology and Microbiology, School of Medicine, University of Southern California, Los Angeles, California, USA

Authors and Affiliations

  1. Department of Epidemiology, The University of Michigan, School of Public Health, Ann Arbor, Michigan, USA

    P. R. Brayton & H. F. Maassab

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  1. P. R. Brayton
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  2. H. F. Maassab
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Brayton, P.R., Maassab, H.F. Characterization of a nonvirulent variant of lymphocytic choriomeningitis virus. Archives of Virology 74, 85–89 (1982). https://doi.org/10.1007/BF01320786

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  • DOI: https://doi.org/10.1007/BF01320786

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