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Amino Acid Mediated Borane Reduction of Ketones

Durch Aminosäuren vermittelte Reduktion von Ketonen mit Boran

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Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Summary.

 Acetophenone, 2,2-dimethylcyclopentanone, 3,3-dimethyl-2-butanone, 3-methyl-2-butanone, and 2-pentanone were reduced with (S)-proline- and (S)-phenylalanine-mediated borane in good to very good yields giving predominantly (32–86% ee) alcohols of (R)-configuration.

Zusammenfassung.

 Acetophenon, 2,2-Dimethylcyclopentanon, 3,3-Dimethyl-2-butanon, 3-Methyl-2-butanon und 2-Pentanon wurden mit Hilfe von Boran in Gegenwart von (S)-Prolin und (S)-Phenylalanin in guten bis sehr guten Ausbeuten reduziert, wobei vornehmlich (32–86%ee) die (R)-konfigurierten Alkohole erhalten wurden.

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Authors and Affiliations

  1.  Faculty of Science, University of Kragujevac, YU-34000, Kragujevac, Yugoslavia, , , , ,

    Aleksandar V. Teodorović, Milan D. Joksović, Stanimir K. Konstantinović & Biljana M. Mojsilović

  2.  Faculty of Chemistry, University of Belgrade, Yugoslavia, , , , ,

    Mihailo L. Mihailović

Authors
  1. Aleksandar V. Teodorović
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  2. Milan D. Joksović
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  3. Stanimir K. Konstantinović
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  4. Biljana M. Mojsilović
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  5. Mihailo L. Mihailović
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Additional information

Received January 20, 1999./Accepted (revised) March 17, 1999

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Teodorović, A., Joksović, M., Konstantinović, S. et al. Amino Acid Mediated Borane Reduction of Ketones. Monatshefte fuer Chemie 131, 91–95 (2000). https://doi.org/10.1007/s007060050010

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  • DOI: https://doi.org/10.1007/s007060050010

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