Summary
Dietary casein, compared to vegetable protein, causes hypercholesterolemia in some animal species. This may be associated with a change of hormonal status. Among others, GH has an important impact on cholesterol metabolism; GH deficiency results in hypercholesterolemia.
This paper shows that the rhythmic variation of GH levels in rats is differently affected by different dietary proteins. Within a 4-h observation period overall mean values and integrated areas under the GH levels plotted against time are higher with casein as compared to soy protein. Secretory GH peak values are lower than reported before for chow-fed rats. These observations support the idea that different dietary proteins cause a different endocrine response.
As GH levels are higher with casein, while lower levels would be expected to be associated with hypercholesterolemia, the observed differences are obviously of less relevance for the expression of casein-induced hypercholesterolemia.
Zusammenfassung
Casein, im Gegensatz zu pflanzlichen Proteinen, führt bei einigen Tierspezies zu Hypercholesterinämie. Dies könnte mit einer Änderung des Hormonstatus einhergehen. Neben anderen Hormonen hat das Wachstumshormon (GH) eine wichtige Rolle in der Regulation des Cholesterinstoffwechsels. Ein GH-Mangel führt zu Hypercholesterinämie.
Diese Untersuchung zeigt, daß die zyklischen Schwankungen der GH-Spiegel durch die Art des Nahrungsproteins beeinflußt werden. Die GH-Mittelwerte und die errechnete Fläche unter den GH-Spiegeln über 4 Stunden sind bei Caseingefütterten Tieren höher als bei Sojaprotein-gefütterten Tieren. Höhere GH-Spiegel in Casein-gefütterten im Vergleich zu Gluten-gefütterten Tieren wurden bereits beobachtet. Unsere Daten unterstützen also die These, daß verschiedene Nahrungsproteine zu unterschiedlichen endokrinen Antworten führen.
Da aber niedrige GH-Spiegel die Voraussetzung für die Ausbildung einer Hypercholesterinämie sind, können die beobachteten Unterschiede nicht die Basis für die Ausprägung einer Casein-induzierten Hypercholesterinämie sein.
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Pfeuffer, M., Wuttke, W. & Barth, C.A. Influence of different dietary proteins on plasma growth hormone in rats. Z Ernährungswiss 27, 229–235 (1988). https://doi.org/10.1007/BF02019511
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DOI: https://doi.org/10.1007/BF02019511