Abstract
Myocytes from failing human ventricle contract and relax more slowly than those from non-failing. This has been suggested to result from the lowering of basal cyclic AMP level in failing myocardium, and the consequent withdrawal of a tonic lusitropic effect. We present data to support this hupothesis by demonstrating that the acceleration of contraction and relaxation by β-adrenoceptor stimulation is greater in myocytes from failing than nonfailing heart. This is despite the desensitisation of the inotropic effect of isorenaline in the same failing cells. Following β-adrenoceptor stimulation, speeds of contraction and relaxation are normalised in myocytes from failing heart, with final values not significantly different from non-failing.
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Harding, S.E., Brown, L.A., del Monte, F. et al. Acceleration of contraction by β-adrenoceptor stimulation is greater in ventricular myocytes from failing than non-failing human hearts. Basic Res Cardiol 91 (Suppl 1), 53–56 (1996). https://doi.org/10.1007/BF00795363
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DOI: https://doi.org/10.1007/BF00795363