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Potential role of endothelin-1 and endothelin antagonists in cardiovascular diseases

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Abstract

The endothelins comprise a family of three isopeptides ET-1, ET-2 and ET-3, whereby ET-1 appears to be the most relevant in humans. They act in a paracrine manner on ETA and ETB receptors. ET-1 plays an important role in the cardiovascular system. In addition, it modulates vasomotion and growth processes, and it participates in thrombogenesis and neutrophil adhesion. This review summarizes some of the current literature pertaining to the physiological and pathophysiological significance of ET-1, focusing the assets and drawbacks of elevated ET-1 levels. In this regard, modulation of the endothelin system by either receptor blockade or by inhibition of endothelin converting enzyme is expected to provide novel therapeutic drug strategies.

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Authors and Affiliations

  1. Zentrum für Operative Medizin I, Forschungsgruppe Experimentelle Chirurgie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany, E-mail: schmispa@uni-duesseldorf.de, , , , , , DE

    Simone Schmitz-Spanke

  2. Center of Biomedical Research, Heinrich-Heine-University Düsseldorf, , , , , , DE

    J. D. Schipke

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  1. Simone Schmitz-Spanke
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  2. J. D. Schipke
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Received: 13 September 1999, Returned for revision: 2 November 1999, Revision received: 2 March 2000, Accepted: 23 March 2000

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Schmitz-Spanke, S., Schipke, J. Potential role of endothelin-1 and endothelin antagonists in cardiovascular diseases. Basic Res Cardiol 95, 290–298 (2000). https://doi.org/10.1007/s003950070048

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  • DOI: https://doi.org/10.1007/s003950070048

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