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Helix formation by poly{bis(hydroxyethyl)-L-glutamine}

  • Polymer Science
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Abstract

Circular dichroism spectra are reported for poly {bis(hydroxyethyl)-L-glutamine}. Its conformation is predominantly that of a statistical coil at or above ambient temperature in water. It becomes partially helical upon cooling. The helix-forming potential of this polypeptide in water is between that of poly(hydroxyethyl-L-glutamine) and poly(hydroxypropyl-L-glutamine). The polypeptide has a large helix content when the solvent is rich in trifluoroethanol.

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Author notes

  1. W. L. Mattice

    Present address: Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana, USA

  2. D. S. Clark

    Present address: Allergan Pharmaceuticals, Irvine, California

Authors and Affiliations

  1. Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana, USA

    L. Tilstra, T. C. Strickland & D. S. Clark

Authors
  1. L. Tilstra
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  2. T. C. Strickland
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  3. D. S. Clark
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  4. W. L. Mattice
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Tilstra, L., Strickland, T.C., Clark, D.S. et al. Helix formation by poly{bis(hydroxyethyl)-L-glutamine}. Colloid & Polymer Sci 264, 469–472 (1986). https://doi.org/10.1007/BF01421998

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  • DOI: https://doi.org/10.1007/BF01421998

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