Abstract
The daily rhythms of melatonin, cortisol and body temperature were studied in 16 institutionalized subjects with the Lennox-Gastaut syndrome. The results of 9 subjects with normal daily rhythms of sleep and wakefulness (group 1) were compared with those of 7 subjects with disordered sleep (group 2). Salivary samples were collected and axillary temperature was measured every 2 h during two or three separate 26-h periods. The hormones were measured by radioimmunoassays. The rhythms were characterized with single cosinor analysis. Two subjects in group 1 and six subjects in group 2 had abnormalities in their rhythms of temperature, cortisol or melatonin. All three rhythms were disrupted in two subjects of group 2. These two subjects were the only ones with disrupted cortisol rhythm. The diversity of rhythm pathologies suggested partly separate regulatory mechanisms for each rhythm. The co-occurrence of circadian rhythm sleep disorders with the deteriorated melatonin rhythm raised the question as to whether the sleep disorders of these subjects, like those of subjects with healthy brains, could be relieved by the induction of normal melatonin rhythm.
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Abe K, Kroning J, Greer MA, Critchlow V (1979) Effects of destruction of the suprachiasmatic nuclei on the circadian rhythms in plasma corticosterone, body temperature, feeding and plasma thyrotropin. Neuroendocrinology 29:119–131
Albers HE, Lydic R, Moore-Ede MC (1984) Role of the suprachiasmatic nuclei in the circadian timing system of the squirrel monkey. 11. Light-dark cycle entrainment. Brain Res 300:285–293
Arato M, Grof E, Grof P, Laszlo I, Brown GM (1985) Reproducibility of the overnight melatonin secretion pattern in healthy men. In: Brown GM, Wainwright SD (eds) The pineal gland: endocrine aspects. (Advances in the biosciences, vol 53) Pergamon Press, Oxford, pp 277–282
Arendt J (1988) Melatonin. Clin Endocrinol 29:205–229
Arendt J, Aldhous M, Marks V (1986) Alleviation of “jet-lag” by melatonin: preliminary results of a controlled double-blind trial. BMJ 292:1170–1172
Bingham C, Arbocast B, Guillaume GC, Lee J-K, Halberg F (1982) Inferential statistical methods for estimating and comparing cosinor parameters. Chronobiologia 9:397–439
Braunsdorf WE, Torn JC, Hildebrandt G, Hoffman O, Müller H (1986) Biological rhythms of electrophysiological and endocrinological parameters in acute and chronic intracranial lesions. Adv Neurosurg 14:340–346
Commision on Classification and Terminology of theInternational League Against Epilepsy (1989) Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 30:389–399
Dallman MF (1984) Viewing the ventromedial hypothalamus from the adrenal gland. Am J Physiol 246:R1-R12
Dauch WA, Bauer S (1990) Circadian rhythms in the body temperatures of intensive care patients with brain lesions. J Neurol Neurosurg Psychiatry 53:345–347
Eastman CI, Mistlberger RE, Rechtschaffen A (1984) Suprachiasmatic nuclei lesions eliminate circadian temperature and sleep rhythms in the rat. Physiol Behav 32:357–368
Ferrari E, Fraschini F, Brambilla F (1990) Hormonal circadian rhythms in eating disorders. Biol Psychiatry 27:1007–1020
Folkard S, Arendt J, Aldhous M, Kennett H (1990) Melatonin stabilises sleep onset time in a blind man without entrainment of cortisol or temperature rhythms. Neurosci Lett 113:193–198
Healy D, Waterhouse JM (1990) The circadian system and affective disorders - clocks or rhythms. Chronobiol Int 7:5–10
Krieger DT (1980) Ventromedial hypothalamic lesions abolish food-shifted circadian adrenal and temperature rhythmicity. Endocrinology 106:649–654
Laakso M-L, Porkka-Heiskanen T, Alila A, Stenberg D, Johansson G (1990) Correlation between salivary and serum melatonin: dependence on serum melatonin levels. J Pineal Res 9:39–50
Laakso M-L, Porkka-Heiskanen T, Stenberg D, Alila A (1991) Interindividual differences in the responses of serum and salivary melatonin to light. In: Fraschini F, Reiter RJ (eds) Role of melatonin and pineal peptides in neuroimmunomodulation. Plenum Press, New York, pp 307–311
Miyamoto A, Hara M, Ito M, Hayashi K, Fukuyama Y (1990) Serum melatonin kinetics in epileptic children with or without photosensitivity. Jpn J Psychiatry Neurol 44:432–433
Monk TH (1991) Sleep and circadian rhythms. Exp Gerontol 26:233–243
Monk TH, Fort A (1983) ‘COSINA’: a cosine curve fitting program suitable for small computers. Int J Chronobiol 8:193–224
Moore RY, Eichler VB (1972) Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat. Brain Res 42:201–206
Moore-Ede MC (1983) The circadian timing system in mammals: two pacemakers preside over many secondary oscillators. Fed Proc 42:2802–2808
Nocke-Finck L, Burgsdorff HH von, Wassmann H, Breuer H (1978) Growth hormone and cortisol in plasma of patients with traumatic apallic syndrome. Acta Endocrinol (Copenh) 87:12
Okawa M, Takahashi K, Sasaki H (1986) Disturbance of circadian rhythms in severely brain-damaged patients correlated with CT findings. J Neurol 233:278–282
Okuyama H, Endo M, Ohara Y, Takase S, Itahara K (1977) Circadian rhythm of the plasma cortisol level in cases of prolonged coma. Tohoku J Exp Med 123:33–47
Page RB, Galicich JH, Grunt JA (1973) Alteration of circadian temperature rhythm with third ventricular obstruction. J Neurosurg 38:309–319
Rao ML, Stefan H, Bauer J, Burr W (1990) Hormonal changes in patients with partial epilepsy - attenuation of melatonin and prolactin circadian serum profiles. In: Dreifuss PE, Meinardi H, Stefan H (eds) Chronopharmacology in therapy of the epilepsies. Raven Press, New York, pp 55–70
Ratge D, Knoll E, Diener U, Hadjidimos A, Wisser H (1982) Circadian rhythm of catecholamines, cortisol and prolactin is altered in patients with apallic syndrome in comparison with normal volunteers. Acta Endocrinol (Copenh) 101:428–435
Reppert SM, Perlow MJ, Ungerleider LG, Mishkin M, Tamarkin L, Orloff DG, Hoffman HJ, Klein DC (1981) Effects of damage to the suprachiasmatic area of the anterior hypothalamus on daily melatonin and cortisol rhythms in the Rhesus monkey. J Neurosci 1:1414–1425
Sack J, Sazbon L, Lunenfeld B, Najenson T (1983) Hypothalamic-pituitary function in patients with prolonged coma. J Clin Endocrinol Metab 56:635–638
Sugden D (1989) Melatonin biosynthesis in the mammalian pineal gland. Experientia 45:922–932
Vakkuri O (1985) Diurnal rhythm of melatonin in human saliva. Acta Physiol Scand 124:409–412
Vakkuri O, Leppäluoto J, Vuolteenaho O (1984) Development and validation of a melatonin radioimmunoassay using radioiodinated melatonin as tracer. Acta Endocrinol (Copenh) 106:152–157
Vining RF, McGinley RA (1987) The measurement of hormones in saliva: possibilities and pitfalls. J Steroid Biochem 27:81–94
Vogel HP, Kroll M, Fritschka E, Quabbe HJ (1990) 24-hour profiles of growth hormone, prolactin and cortisol in the chronic vegetative state. Clin Endocrinol 33:631–643
Wehr TA, Sack D, Rosenthal N, Duncan W, Gillin JC (1983) Circadian rhythm disturbances in manic-depressive illness. Federation Proc 42:2809–2814
Winfree AT (1982) Human body clocks and the timing of sleep. Nature 297:23–27
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Laakso, M.L., Leinonen, L., Hätönen, T. et al. Melatonin, cortisol and body temperature rhythms in Lennox-Gastaut patients with or without circadian rhythm sleep disorders. J Neurol 240, 410–416 (1993). https://doi.org/10.1007/BF00867353
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DOI: https://doi.org/10.1007/BF00867353