Summary
The cases of two epileptic identical twins are described, one of whom had presented an episode of valproate (VPA)-induced stupor associated with very high blood ammonia (NH3) concentrations. Both twins showed a similar marked increase of venous NH3 concentrations after the administration of a single loading dose of VPA (800 mg).
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Campostrini, R., Zaccara, G., Rossi, L. et al. Valproate-induced hyperammonaemia in two epileptic identical twins. J Neurol 232, 167–168 (1985). https://doi.org/10.1007/BF00313894
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DOI: https://doi.org/10.1007/BF00313894