Summary
Five common tricyclic antidepressants are separated on a silica column using an aqueous eluent. The tricyclics are concentrated from serum using an adsorption procedure on a solid phase Sep PakTM C18 cartridge. The method appears to be adequate for monitoring therapeutic levels of these drugs.
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Dedicated to Professor Dr. István Halász for his 60th birthday.
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Bidlingmeyer, B.A., Korpi, J. & Little, J.N. Determination of tricyclic antidepressants using silica gel with a reversed-phase eluent. Chromatographia 15, 83–85 (1982). https://doi.org/10.1007/BF02290438
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DOI: https://doi.org/10.1007/BF02290438