Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

A minor groove binding track in reverse transcriptase

Evidence is presented indicating that processive synthesis by HIV-1 reverse transcriptase involves interactions between the minor groove of the template-primer and a discrete protein structural element, the minor groove binding track (MGBT).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Harrison, S.C. Nature 353, 715–719 (1991).

    Article  CAS  PubMed  Google Scholar 

  2. Churchill, M.E.A. & Travers, A.A. TIBS 16, 92–97 (1991).

    CAS  PubMed  Google Scholar 

  3. Doherty, A.J., Serpell, L.C. & Ponting, C.P. Nucleic Acids Res. 24, 2488–2497 (1996).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Chandra, A. et al. FEBS Lett. 200, 327–332 (1986).

    Article  CAS  PubMed  Google Scholar 

  5. di Marzo Veronese, F. et al. Science 231, 1289–1291 (1986).

    Article  CAS  PubMed  Google Scholar 

  6. Lightfoote, M.M. et al. J. Virol. 60, 771–775 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Ollis, D.L., Brick, P., Hamlin, R., Xuong, N.G. & Steitz, T.A. Nature 313, 762–766 (1985).

    Article  CAS  PubMed  Google Scholar 

  8. Kohlstadt, L.A., Wang, J., Freidman, J.M., Rice, P.A. & Steitz, T.A. Science 256, 1783–1790 (1992).

    Article  Google Scholar 

  9. Sousa, R., Chung, Y.J., Rose, J.P. & Wang, B.-C. Nature 364, 593–599 (1993).

    Article  CAS  PubMed  Google Scholar 

  10. Pelletire, H. et al. Science 264, 1891–1903 (1994).

    Article  Google Scholar 

  11. Eom, S.H., Wang, J. & Steitz, T.A. Nature 382, 278–281 (1996).

    Article  CAS  PubMed  Google Scholar 

  12. Jacobo-Molina, A. et al. Proc. Natl. Acad. Sci. U.S.A. 90, 6320–6324 (1993).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Unge, T. et al. Structure 2, 953–961 (1994).

    Article  CAS  PubMed  Google Scholar 

  14. Esnouf, R. et al. Nat. Struct. Biol. 2, 303–308 (1995).

    Article  CAS  PubMed  Google Scholar 

  15. Ren, J. et al. Nat. Struct. Biol. 2, 293–302 (1995).

    Article  CAS  PubMed  Google Scholar 

  16. Beard, W.A. et al. J. Biol. Chem. 269, 28091–28097 (1994)

    CAS  PubMed  Google Scholar 

  17. Bebenek, K. et al. J. Biol. Chem. 270, 19516–19523 (1995).

    Article  CAS  PubMed  Google Scholar 

  18. Beard, W.A. et al. J Biol. Chem. 271, 12213–12210 (1996).

    Article  CAS  PubMed  Google Scholar 

  19. Beese, L.A., Derbyshire, V. & Steitz, T.A. Science 260, 352–355 (1993).

    Article  CAS  PubMed  Google Scholar 

  20. Steitz, T.A. in Biological Organization: Macromolecular Interactions at High Resolution (eds. Burnett, R. & Vogel, H.J.) 45–55 (Academic Press, NY, 1987).

    Google Scholar 

  21. Beard, W.A. et al. J Biol. Chem. 271, 12141–12144 (1996).

    Article  CAS  PubMed  Google Scholar 

  22. Pearlman, D.A. et al. Amber 4.1, University of California, San Francisco (1995).

  23. Darden, T.A., York, D.M. & Pedersen, L. G. J. Chem. Phys. 98, 10089–10092 (1993).

    Article  CAS  Google Scholar 

  24. Beard, W.A. & Wilson, S.H. Biochemistry 32, 9745–9753 (1993).

    Article  CAS  PubMed  Google Scholar 

  25. Bebenek, K. & Kunkel, T. A. Meth. Enzymol. 262, 217–231 (1995).

    Article  CAS  Google Scholar 

  26. Kroutil, L.C., Register, K., Bebenek, K. & Kunkel, T.A. Biochemistry 35, 1046–1053 (1995).

    Article  Google Scholar 

  27. Kraulis, P. J. Appl. Crystallogr. 24, 946–950 (1991).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bebenek, K., Beard, W., Darden, T. et al. A minor groove binding track in reverse transcriptase. Nat Struct Mol Biol 4, 194–197 (1997). https://doi.org/10.1038/nsb0397-194

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsb0397-194

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing