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Site-directed immunogenesis

Nature Medicine volume 4, pages 547–548 (1998)Cite this article

A fusion DNA vaccine directs antigens to sites where immune cells congregate, enhancing both cellular and humoral immune responses.

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References

  1. Montgomery, D.L., Ulmer, J.B. & Liu, M.A. DNA Vaccines. Pharmacol. Ther. 74, 195–205 (1997).

    PubMed  CAS  Google Scholar 

  2. Hohlfeld, R. & Engel, A.G. The immunobiology of muscle. Immunol. Today 15, 269–275 (1994)

    Article  CAS  Google Scholar 

  3. Raz, E. et al. Intradermal gene immunization: The possible role of DNA uptake in the induction of cellular immunity to viruses. Proc. Natl. Acad. Sci. USA 91, 9519–9523 (1994).

    Article  CAS  Google Scholar 

  4. Boyle, J.S., Brady, J.L. & Lew, A.M. Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction. Nature 392, 408–411 (1998).

    Article  CAS  Google Scholar 

  5. Schweitzer, A.W. & Sharpe, A.H. The complexity of the B7-CD28/CTLA-4 costimulatory pathway. Agents Action Suppl. 49, 33–43 (1998).

    CAS  Google Scholar 

  6. Horspool et al. Nucleic acid vaccine-induced immune responses require CD28 costimulation and are regulated by CTLA4. J. Immunol. 160, 2706–2714 (1998).

    PubMed  CAS  Google Scholar 

  7. Robinson, H.L. & Torres, C.A. DNA vaccines. Semin. Immunol. 9, 271–283 (1997).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Immunology and Molecular Genetics MedImmune, Inc., Gaithersburg, Maryland, 20878, USA

    Solomon Langermann

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  1. Solomon Langermann
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Langermann, S. Site-directed immunogenesis. Nat Med 4, 547–548 (1998). https://doi.org/10.1038/nm0598-547

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  • DOI: https://doi.org/10.1038/nm0598-547

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