Abstract
CERTAIN investigations on animals have suggested the efficacy of treatment of bacterial infections with specific bacteriophage. Dubos et al.1 demonstrated the therapeutic effect of Shigella dysenteriae phage in experimental infections in mice. Morton and Engley2 showed a prophylactic, as well as therapeutic, effect in mice infected with Shigella dysenteriae. Recently, Muir and Blakemore3 protected 70 per cent of mice lethally infected with Staphylococcus aureus type 80/81 with high-titred specific phage given simultaneously with the bacteria.
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References
Dubos, R. J., Straus, H. S., and Pierce, C., J. Exp. Med., 78, 161 (1943).
Morton, H. E., and Engley, F. B., J. Bact., 49, 245 (1945).
Muir, W., and Blakemore, W. S., Surg. Forum, Amer. Coll. Surg., 10, 339 (1960).
Cohn, Z. A., and Morse, S. I., J. Exp. Med., 110, 419 (1959).
Kapral, F. A., and Shayegani, M. G., J. Exp. Med., 110, 123 (1959).
Mackaness, G. B., J. Exp. Med., 112, 35 (1960).
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McKENNA, J., SANDERSON, R. Effect of Phagocytosis on the Lysis of Staphylococcus aureus (Type 81) by Bacteriophage. Nature 192, 570–571 (1961). https://doi.org/10.1038/192570a0
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DOI: https://doi.org/10.1038/192570a0
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