Abstract
THE active transport of inorganic phosphate into the red blood cell is generally believed to be closely related to glycolysis, although the actual mechanism of transfer is unknown1. Gourley2 considered that phosphate enters the erythrocyte through the formation of adenosine triphosphate at the cell surface. Prankerd et al. 3 and Bartlett4 concluded from their investigations that inorganic phosphate is transferred into the cell by incorporation into 1,3-diphosphoglyceric acid. Our own experimental evidence suggests that the transfer of inorganic phosphate is independent of glycolysis.
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References
Gourley, D. R. H., and Gemmill, C. L., J. Cell. and Comp. Physiol., 35, 341 (1950).
Gourley, D. R. H., Arch. Biochem. and Biophys., 40, 1 (1952).
Prankerd, T. A. J., and Altman, K. I., Biochem. J., 58, 622 (1954).
Bartlett, G. R., Ann. N.Y. Acad. Sci., 75, 110 (1958).
Bartlett, G. R., J. Biol. Chem., 234, 449 (1959).
Roe, J. H., Epstein, J. H., and Goldstein, N. P., J. Biol Chem., 178, 839 (1949).
Dische, Z., in McElroy, W. D., and Glass, B., Phosphorus Metabolism, 171 (Johns Hopkins Press, Baltimore, 1951).
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ZIPURSKY, A., ISRAELS, L. Transport of Phosphate into the Erythrocyte. Nature 189, 1013–1015 (1961). https://doi.org/10.1038/1891013a0
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DOI: https://doi.org/10.1038/1891013a0
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