Abstract
A TEMPORARY increase in resistance to infection by certain bacteria has been shown to follow the intravenous injection of minute amounts of lipopoly-saccharides isolated from heterologous Gram-negative organisms1; 0.5 µgm. of most lipopolysaccharide preparations is an effective dose for a 20-gm. mouse. Increased resistance has also been observed following the intravenous injection of other colloidal or particulate materials, such as native dextran2 or ‘Zymosan’3, although only when used in much larger doses, for example, 5–25 mgm. Furthermore, even with this thousand-fold difference in effective dose, the increase in resistance is less than that following bacterial lipopolysaccharide.
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References
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HOWARD, J., ROWLEY, D. & WARDLAW, A. Stimulation Of Non-Specific Immunity by the ‘Lipid A’ Component of Bacterial Lipopolysaccharide. Nature 179, 314–315 (1957). https://doi.org/10.1038/179314a0
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DOI: https://doi.org/10.1038/179314a0
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