Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Biochemical Research on Chemical Warfare Agents

Abstract

THE fundamental mechanisms by which poison gases produce their effects, involving as they do the action of chemical substances on living tissues, are prinftrily a matter for investigation by the biochemist, For some time past the belief has been growylg that many, if not most, poisons act by attacking one or more of the essential intracellular enzymes, thus producing what Peters has termed a ‘biochemical lesion’; the actual damage observed is a consequence of the resulting metabolic disturbances.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ford Moore, Porton Report (1936).

  2. Mackworth, Dixon Report No. 4 (1941).

  3. Morgan and Dixon, Biochemical S.C. Minutes. 28.11.41.

  4. Peters, Biochemical S.C. Minutes. 28.11.41. Appendix 1, note.

  5. Van Heyningen, Dixon Report No. 10 (1941).

  6. Colowick and Kalckar, J. Biol. Chem., 137, 789 (1941).

    CAS  Google Scholar 

  7. Peters, Stocken and Thompson, Nature, 156, 616 (1945).

    Article  ADS  CAS  Google Scholar 

  8. Dixon, Biochem. J. (in preparation).

  9. Dixon, Biochemical S.C. Minutes. 28.11.41.

  10. Dixon and Needham, Biochemical S.C. Minutes. 28.11.41.

  11. Dixon and Needham, Dixon Report No. 12 (1941).

  12. McCombie and Saunders, Nature, 157, 287 (1946).

    Article  ADS  CAS  Google Scholar 

  13. Mackworth, Dixon Report No. 13 (1942).

  14. Webb, Dixon Report No. 27 (1944).

  15. Webb, Biochem. J. (in preparation).

  16. Webb, Biochemical S.C. Minutes. 23.3.44.

  17. Dixon, van Heyningen and Needham, Dixon Report No. 11 (1941).

  18. Sinclair, Thompson and Peters, Peters Report No. 3 (1940).

  19. Mackworth . Personal communication.

  20. Webb and van Heyningen, Dixon Report No. 16 (1942).

  21. Danielli, Mitchell, Owen and Shaw, Dixon Report No. 26 (1944).

  22. Danielli, Mitchell, Owen and Shaw, Nature, 157, 217 (1946).

    Article  ADS  CAS  Google Scholar 

  23. Danielli, Mitchell and Cameron, Dixon Report No. 25 (1944).

  24. Danielli, Dixon Report No. 9 (1941).

  25. Needham and Dixon, Dixon Report No. 1 (1941).

  26. Berenblum, Kendall and Orr, Biochem. J., 30, 709 (1936).

    Article  CAS  Google Scholar 

  27. Lutwak Mann, Biochem. J., 40, v. (1946).

  28. Needham, Dixon and van Heyningen, Dixon Report No. 5 (1941).

  29. Needham and Dixon, Dixon Report No. 14 (1942).

  30. Van Heyningen, Dixon Report No. 3 (1941).

  31. Peters, Nature, 138, 327 (1936).

    Article  ADS  CAS  Google Scholar 

  32. Peters and Wakelin, Peters Report No. 2 (1940).

  33. Holiday, Ogston, Philpot and Stocken, Peters Report No. 1 (1940).

  34. Cannan . By communication (1943).

  35. Dixon and Needham, Dixon Report No. 2 (1941).

  36. Needham, Dixon Report No. 15 (1942).

  37. Cori . By communication (1942).

  38. Dixon Report No. 19 (1943).

  39. Northrop . By communication (1942).

  40. Bergmann . By communication (1942).

  41. Beloff, Peters and Wakelin, Peters Report No. 80 (1945).

  42. Thompson, Peters Report No. 63 (1942).

  43. Bailey and Webb, Dixon Report No. 30 (1944).

  44. Northrop, Kunitz and McDonald . By communication (1943), also J. Gen. Physiol., 29, 143 (1946).

    Google Scholar 

  45. Needham, Cohen and Barrett, Dixon Report No. 22 (1943).

  46. Cori . By communication (1942–44).

  47. Barrett and Greville, Dixon Report No. 32 (1946).

  48. Lutwak Mann, Dixon Report No. 32 (1946).

  49. Boursnell, Cohen, Dixon, Francis, Greville, Needham and Wormall, Joint Reports by Wormall (Nos. 8, 9, 12–14) and Dixon (Nos. 23, 28, 29, 33) (1943–45), also Biochem. J. (in the press).

  50. Boursnell, Francis and Wormall, Wormall Report No. 4 (1942), also Biochem. J. (in press).

  51. Marshall and Williams, J. Pharm., 16, 259 (1920).

    Google Scholar 

  52. Boursnell, Francis and Wormall, Joint Report by Dixon (No. 31) and Wormall (No. 12) (1945), also Biochem. J. (in the press).

  53. Hill and van Heyningen, Dixon Report No. 17 (1942).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

DIXON, M., NEEDHAM, D. Biochemical Research on Chemical Warfare Agents. Nature 158, 432–438 (1946). https://doi.org/10.1038/158432a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/158432a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing