Abstract
PROTEIN stability is usually expressed in terms of the energies required for the micro- and macro-unfolding of its structure, determined from hydrogen exchange and denaturation experiments. Both these characteristics represent qualitatively different properties of a protein macromolecule which can be classified as the rigidity of the structure and the stability of the macroscopic state. In this report, the dependence of these properties on the parameters specifying protein structure is analysed.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Linderström-Lang, K. H. & Schellman, J. A. The Enzymes, Vol. 1, 2nd edn (eds Boyer, P. D., Lardy, H. & Myrback, K.) 443–510 (Academic, New York, 1959).
Hvidt, A. & Nielsen, S. O. Adv. Protein Chem. 21, 287–386 (1966).
Willumsen, L. C. r. Trav. Lab. Carlsberg 38, 223–295 (1971).
Hvidt, A. & Wallevik, K. J. biol. Chem. 247, 1530–1535 (1972).
Anson, M. L. Adv. Protein Chem. 2, 361–368 (1945).
Privalov, P. L. FEBS Lett. 40, S14i–S152 (1974).
Privalov, P. L. & Khechinashvili, N. N. J. molec. Biol. 86, 665–684 (1974).
Tiktopulo, E. I. & Privalov, P. L. Biofizika (USSR) 20, 778–782 (1975).
Hvidt, A. & Pedersen, E. J. Eur. J. Biochem. 48, 333–338 (1974).
Zavodzky, P., Jochansen, J. T. & Hvidt, A. Eur. J. Biochem. 56, 67–72 (1975).
Tiktopulo, E. I. & Privalov, P. L. Biophys. Chem. 1, 349–357 (1974).
Tischenko, V. M. & Gorodkov, V. G. Biofizika (USSR) 24, 334–335 (1979).
Tischenko, V. M., Tiktopulo, E. I. & Privalov, P. L. Biofizika (USSR) 19, 400–404 (1974).
Privalov, P. L. & Khechinashvili, N. N. Biofizika (USSR) 19, 14–18 (1974).
Jackson, W. M. & Brandts, J. F. Biochemistry 9, 2294–2301 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PRIVALOV, P., TSALKOVA, T. Micro- and macro-stabilities of globular proteins. Nature 280, 693–696 (1979). https://doi.org/10.1038/280693a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/280693a0
This article is cited by
-
Protein folding rate evolution upon mutations
Biophysical Reviews (2023)
-
Biophysical characterization of the recombinant chitinase chi18-5 with potential biotechnological interest
Applied Microbiology and Biotechnology (2022)
-
The Marginal Stability of Proteins: How the Jiggling and Wiggling of Atoms is Connected to Neutral Evolution
Journal of Molecular Evolution (2020)
-
About the Protein Space Vastness
The Protein Journal (2020)
-
Hydrogen exchange and the dynamic structure of proteins
Molecular and Cellular Biochemistry (1982)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
