Abstract
IN the peripheral nervous system, acetylcholine (ACh) acts on presynaptic muscarinic receptors to inhibit the release of noradrenaline (NA) from nerve terminals and by way of nicotinic presynaptic receptors to stimulate release1. A NA–ACh interaction has also been postulated2–7 to occur in the central nervous system (CNS). Cholinergic agonists decrease the levels of NA in various brain areas5,6, affect the release of NA in in vitro preparations3,4 and have similar effects in vivo as measured by increased metabolites of NA (ref. 2). A reciprocal interaction, that of NA modulating ACh release in the CNS does not seem to occur, according to evidence8 available at present. We report here that depletion of forebrain NA by intracerebral injection of the selective neurotoxin 6-hydroxydopamine (6-OHDA) almost completely blocks the catalepsy induced by cholinergic agonists such as pilocarpine and arecoline9–12 and enhances the locomotor stimulation caused by the anticholinergic drugs scopolamine and atropine13–15. Although these actions have most usually been ascribed to an interaction with dopamine (DA) systems16,17, our data show that functionally significant interactions between ACh and NA systems also occur.
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References
Westfall, T. C. Physiol. Rev. 57, 659–728 (1977).
Davis, K. L., Hollister, L. E., Goodwin, F. K. & Gordon, E. K. Life Sci. 21, 933–936 (1977).
Westfall, T. C. Life Sci. 14, 1441–1452 (1974).
Westfall, T. C. Neuropharmacology 13, 693–700 (1974).
Glisson, S. N., Karczmar, A. & Barnes, L. Neuropharmocolgy, 11, 465–477 (1972).
Glisson, S. N., Karczmar, A. & Barnes, L. Neuropharmacology 13, 623–632 (1974).
Reader, T. A., De Champlain, J. & Jasper, H. Brain Res. 111, 95–107 (1976).
Barnes, L., Cann, F., Karczmar, A. G., Kindel, G. & Longo, V. G. Pharmac. Biochem. Behav. 1, 35–40 (1973).
Zetler, G. Int. J. Neuropharmac. 7, 325–335 (1968).
Timsit, J. Therapie 21, 1453–1455 (1966).
Baez, L. A., Eskridge, N. K. & Schein, R. Eur. J. Pharmac. 36, 155–161 (1976).
Costall, G. & Olley, J. Neuropharmacology 10, 297–301 (1971).
Pradham, S. N. & Roth, T. Psycopharmacology 12, 358–361 (1968).
Campbell, B. A., Lytle, L. & Fibiger, H. C. Science 166, 637–638 (1969).
Fibiger, H. C., Lytle, L. & Campbell, B. A. J. comp. Physiol. Psychol. 72, 384–391 (1970).
Roberts, D. C. S., Zis, A. P. & Fibiger, H. C. Brain Res. 93, 441–450 (1975).
Creese, I. & Iversen, S. D. Brain Res. 83, 419–436 (1975).
Uretsky, N. J. & Iversen, L. L. Nature 221, 557–559 (1969).
Ungerstedt, U. Acta physiol. scand. suppl. 367, 1–49 (1971).
Lindvall, O. & Bjorklund, A., Acta Physiol. scand. suppl. 412, 1–48 (1974).
McGeer, E. G. & McGeer, P. L. Can. J. Biochem. 40, 1141–1151 (1962).
Siegel, S. Nonparametric Statistics (McGraw-Hill, New York, 1956).
Winer, B. J. Statistical Principles in Experimental Design (1962).
Lidbrink, P. Brain Res. 74, 19–40 (1974).
Lidbrink, P. & Fuxe, K. J. Pharm. Pharmac. 25, 84–87 (1973).
Bird, S. J. & Kuhar, M. J. Brain Res. 122, 523–533 (1977).
Papp, M. & Bozsik, G. J. Neurochem. 13, 697–703 (1966).
Pavlin, R. J. Neurochem. 12, 515–518 (1966).
Scheibel, M. E. & Scheibel, A. B. Brain Inf. Serv. Conf., Rep. No. 32 Brain Information Service, Brain Research Institute, Los Angeles, 1973.
Amatruda, T. T., Black, D. A., McKenna, T. M., McCarley, R. W. & Hobson, J. A. Brain Res. 98, 501–515 (1975).
Mitler, M. M. & Dement, W. C. Brain Res. 68, 335–346 (1974).
van Dongen, P. A. M., Broekkamp, C. L. E. & Cools, A. R. Pharm. Biochem. Behav. (in the press).
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MASON, S., FIBIGER, H. Possible behavioural function for noradrenaline–acetylcholine interaction in brain. Nature 277, 396–397 (1979). https://doi.org/10.1038/277396a0
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DOI: https://doi.org/10.1038/277396a0
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