Abstract
SINCE electron microscopy has enabled the identification of vesicles which appear concentrated at anatomically defined synaptic sites, a theory has been proposed that the transmitter released at the synapses is of vesicular origin. The synaptic vesicles had a high content of acetylcholine (ACh)1–3 and were ideal carriers of ‘packets’ of ACh released at the synapse, a necessary requirement for the quantal theory of transmission4.
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TAUC, L., HOFFMANN, A., TSUJI, S. et al. Transmission abolished on a cholinergic synapse after injection of acetylcholin-esterase into the presynaptic neurone. Nature 250, 496–498 (1974). https://doi.org/10.1038/250496a0
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DOI: https://doi.org/10.1038/250496a0
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