Abstract
RIBONUCLEIC acid-dependent RNA polymerase (replicase) was first isolated from Escherichia coli infected with RNA bacteriophage Q β which has specific template requirements1. Such an enzyme has been described in tumour cells and several types of mammalian cells infected with RNA viruses2–5.
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References
Haruna, I., and Spiegelman, S., Proc. natn. Acad. Sci. U.S.A., 54, 579 (1965).
Wykes, J. R., and Smellie, R. M. S., Biochem, J., 99, 347 (1966).
Burdon, R. H., and Smellie, R. M. S., Biochim. biophys. Acta, 51, 153 (1961).
Watson, K. F., and Beaudreau, G. S., Biochem. biophys. Res. Commun., 37, 925 (1969).
Haruna, I., Ohno, T., Hozumi, N., and Watanabe, I., Gann Monograph on Cancer Research, 12, 203 (1972).
Winters, M. A., and Edmonds, M., J. biol. Chem., 248, 4756 (1973).
Dravid, A. R., Pete, N., and Mandel, P., J. Neurochem., 18, 299 (1971).
Hyatt, E. A., Biochem. biophys. Acta., 142, 246 (1967).
Niessing, J., and Sekeris, C. E., Nature New Biol., 243, 9 (1973).
Wilkie, N. M., and Smellie, R. M. S., Biochem. J., 109, 485 (1968).
Mandel, P., and Jacob, M., in Handbook of Neurochemistry, (edit. by Lajtha, A.) 5, Part A, 165 (Plenum Press, New York and London, 1971).
Mikoshiba, K., Tsukada, Y., Haruna, I., Ohno, T., and Watanabe, I., Abstr. fourth Int. Mtg. Int. Soc. Neurochem., Tokyo, Japan, 290 (1973).
Widnell, C. C., and Tata, J. R., Biochim. biophys. Acta, 123, 478 (1966).
Roeder, R. G., and Rutter, W. J., Proc. natn. Acad. Sci. U.S.A., 65, 675 (1970).
Kamen, R., Kondo, M., Romer, W., and Weissmann, C., Eur. J. Biochem., 31, 44 (1972).
Nishihara, T., Haruna, I., Yamaguchi, N., and Watanabe, I., Nature new Biol., 238, 141 (1972).
Sarker, P. K., Goldman, B., and Moscona, A. A., Biochem. biophys. Res. Commun., 50, 308 (1973).
Bollum, F. J., in Methods in Enzymology (edit. by Grossman, L., and Moldave, K.) 12, Part B, 591 (Academic Press, New York and London, 1968).
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MIKOSHIBA, K., TSUKADA, Y., HARUNA, I. et al. RNA-dependent RNA synthesis in rat brain. Nature 249, 445–448 (1974). https://doi.org/10.1038/249445a0
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DOI: https://doi.org/10.1038/249445a0
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