Abstract
BY electrophoretic analysis we have found large quantities of an exceptionally basic protein in the urine of five out of seven consecutive cases of chronic myelocytic leukaemia. In four cases the specific proteinuria occurred when induction of remission was achieved after X-irradiation directed against the enlarged spleen. In one case the protein was found before X-ray therapy, but irradiation evoked an increasing protein response. The proteins have been isolated and characterized as relatively low molecular weight constituents with the enzymatic properties of lysozyme.
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References
Osserman, E. F., and Lawlor, D. P., J. Exp. Med., 124, 921 (1966).
Pruzanski, W., and Saito, S. G., Amer. J. Med. Sci., 258, 405 (1969).
Tischendorf, F. W., and Osserman, E. F., Protides Biol. Fluids, 16, 197 (1969).
Fink, M. E., and Finch, S. C., Proc. Soc. Exp. Biol. NY, 127, 365 (1968).
Hansen, N. E., Karle, H., and Andersen, V., Acta Med. Scand., 185, 387 (1969).
Perillie, P. E., Kaplan, S. S., and Finch, S. C., New Engl. J. Med., 277, 10 (1967).
Cohn, Z. A., and Hirsch, J. G., J. Exp. Med., 112, 983 (1960).
Zeya, H. J., and Spitznagel, J. K., Science, 142, 1085 (1963).
Fleming, A., and Allison, V. D., Brit. J. Exp. Pathol., 13, 252 (1922).
Jollès, P., Sternberg, M., and Mathé, G., Israel J. Med. Sci., 1, 445 (1965).
Briggs, R. S., Perillie, P. E., and Finch, S. C., J. Histochem. Cytochem., 14, 167 (1966).
Noble, R. E., and Fudenberg, H. H., Blood, 30, 465 (1967).
Asamer, H., Schmalzl, F., and Braunsteiner, H., Brit. J. Haematol. (in the press).
Baiki, A. G., Court-Brown, W. M., Buckton, K. E., Harnden, D. G., Jacobs, P. A., and Tough, I. M., Nature, 188, 1165 (1960).
Nowell, P. C., and Hungerford, D. A., J. Nat. Cancer Inst., 25, 85 (1960).
Perillie, P. E., and Finch, S. C., New Engl. J. Med., 283, 456 (1970).
Tischendorf, F. W., and Osserman, E. F., Fed. Proc., 26, 845 (1967).
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TISCHENDORF, F., LEDDEROSE, G., MÜLLER, D. et al. Heavy Lysozymuria after X-Irradiation of the Spleen in Human Chronic Myelocytic Leukaemia. Nature 235, 274–275 (1972). https://doi.org/10.1038/235274b0
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DOI: https://doi.org/10.1038/235274b0
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