Abstract
THE diversity of actions of catecholamines at β-receptors led Lands1 to suggest that there are two β-receptor populations; β “1” concerned with lipolysis and cardiac stimulation, and β “2” with bronchodilatation and vasodepression. We have investigated this in conscious man by comparing the effects of isoprenaline with isoetharine (a β-receptor stimulant) on heart rate, diastolic blood pressure, peripheral blood flow and respiratory minute volume. Our results support Lands's hypothesis and also suggest that the respiratory stimulation produced in man by β-receptor stimulants is a β 1 action and is not linked with bronchodilatation.
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References
Lands, A. M., Arnold, A., McAuliff, J. P., Luduena, F. P., and Brown, jun., T. G., Nature, 214, 597 (1967).
Lands, A. M., Luduena, F. P., Grant, J. I., and Ananenko, E. J., Pharmacol. Exp. Therap., 99, 45 (1950).
Herschfus, J. A., Bresnick, E., Levinson, L., and Segal, M. S., Ann. Allergy, 9, 769 (1951).
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COLLIER, J., DORNHORST, A. Evidence for Two Different Types of βReceptors in Man. Nature 223, 1283–1284 (1969). https://doi.org/10.1038/2231283a0
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DOI: https://doi.org/10.1038/2231283a0
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