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Bistability caused by Substrate Inhibition of Peroxidase in an Open Reaction System

Abstract

SEVERAL, authors have suggested that more than one stable stationary state exists in an open homogeneous reaction system, and this suggestion has served as a basis for speculative explanations of various biological phenomena1–4. Although bistability is well known in open heterogeneous chemical reaction systems, as for example an electrolysis cell with a passivable electrode6, it seems that bistability has never been observed in an open homogeneous system. This communication describes such a case.

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References

  1. Denbigh, K. G., Hicks, M., and Page, F. M., Trans. Faraday Soc., 44, 47 (1948).

    Article  Google Scholar 

  2. Szilard, L., Proc. US Nat. Acad. Sci., 46, 277 (1960).

    Article  ADS  CAS  Google Scholar 

  3. Kacser, H., Soc. Exp. Biol. Symp., 14, 13 (1960).

    CAS  Google Scholar 

  4. Anker, H. S., Nature, 188, 938 (1960).

    Article  ADS  CAS  Google Scholar 

  5. Monod, J., and Jacob, F., Cold Spring Harbor Symp. Quant. Biol., 26, 389 (1961).

    Article  CAS  Google Scholar 

  6. Franck, U. F., Elektrochem., 62, 649 (1958).

    CAS  Google Scholar 

  7. Yamazaki, I., Yokota, K., and Nakajima, R., Biochem. Biophys. Res. Commun., 21, 582 (1965).

    Article  CAS  Google Scholar 

  8. Yamazaki, I., and Yokota, K., Biochim. Biophys. Acta, 132, 310 (1967).

    Article  CAS  Google Scholar 

  9. Keilin, D., and Mann, T., Proc. Roy. Soc., B, 122, 119 (1937).

    Article  ADS  CAS  Google Scholar 

  10. Sel'koy, E. E., in Some Biocybernetics Problems, Application of Electronics to Biology and Medicine (edit. by Anosov, N. M.) 1 (Naukova Dumka, Kiev, 1966).

    Google Scholar 

  11. Higgins, J., Mémoires Acad. Roy. Med. Belgique, 6, 235 (1967).

    Google Scholar 

  12. Higgins, J., Ind. Eng. Chem., 59 (5), 19 (1967).

    Article  Google Scholar 

  13. Harrison, D. E. F., and Pirt, S. J., J. Gen. Microbiol., 46, 193 (1967).

    Article  CAS  Google Scholar 

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DEGN, H. Bistability caused by Substrate Inhibition of Peroxidase in an Open Reaction System. Nature 217, 1047–1050 (1968). https://doi.org/10.1038/2171047b0

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  • DOI: https://doi.org/10.1038/2171047b0

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