Abstract
VITAMIN A, when administered topically or systemically in high doses, retards the growth and inhibits the induction of benign and malignant tumours1–3. When it is applied locally, vitamin A inhibits the development of tumours of the cervix and vagina of hamsters induced by 9,10-dimethyl-1,2-benzanthracene (DMBA), but has no protective effect on the perineal skin1. Topical application of excessive vitamin A, however, is known to cause epithelial hyperplasia and mild atypicality, disorientation of the basal layer4–6, rapid epithelial proliferation7 and mucoid metaplasia, with the formation of gland-like structures8,9; and an increased incidence of avian leukosis has recently been reported in response to excess vitamin A (ref. 10). We describe here the effect of topical hypervitaminosis A on the induction by DMBA of carcinoma in the hamster cheek pouch.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Chu, E. W., and Malmgren, R. A., Cancer Res., 25, 884 (1965).
McMichael, H., Cancer Res., 25, 947 (1965).
Davies, R. E., Cancer Res., 27, 237 (1967).
Bern, H. A., Nature, 174, 509 (1954).
Bern, H. A., Elias, J. J., Picket, P. I., Powers, T. R., and Harkness, M. N., Amer. J. Anat., 46, 419 (1955).
Jackson, S. F., and Fell, H. B., Develop. Biol., 7, 394 (1963).
Lawrence, D. J., and Bern, H. A., Exp. Cell Res., 21, 443 (1960).
Lawrence, D. J., and Bern, H. A., J. Invest. Dermatol., 31, 313 (1958).
Lawrence, D. J., Bern, H. A., and Steadman, M. G., Ann. Otol. Rhinol. Laryngol., 69, 645 (1960).
March, B. E., and Biely, J., Nature, 214, 287 (1967).
Levij, I. S., Polliack, A., and Thorgeirsson, T., Arch. Oral Biol., 12, 859 (1967).
Lucy, J. A., and Dingle, J. T., Nature, 204, 156 (1964).
Dingle, J. T., and Lucy, J. A., Proc. Nutrit. Soc., 24, 170 (1965).
Dingle, J. T., Biochem. J., 79, 509 (1961).
Dingle, J. T., Sharman, I. M., and Moore, T., Biochem. J., 98, 476 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
POLLIACK, A., LEVIJ, I. Increased Incidence of Carcinoma induced by DMBA in the Hamster Cheek Pouch in response to Vitamin A. Nature 216, 187–188 (1967). https://doi.org/10.1038/216187a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/216187a0
This article is cited by
-
Untersuchungen �ber den Effekt der chronischen Zigarettenrauchinhalation beim syrischen Goldhamster und �ber die Bedeutung des Vitamin A auf die bei Berauchung gefundenen Organver�nderungen
Zeitschrift f�r Krebsforschung und Klinische Onkologie (1977)
-
The effect of ultraviolet light (UVL) on the lysosomes of hairless mouse epidermis
Experientia (1977)
-
Inhibition of tumorigenesis by topical application of low doses of vitamin A acid and fluorouracil
Experientia (1975)
-
The effect of membrane-active agents on the mitotic frequency in normal and carcinogen-treated epithelium
Experientia (1972)
-
Increased Incidence of Rous Sarcomas in Response to Excess Vitamin A
Nature (1971)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
