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Postulated Chemical Basis for Observed Differences in the Enzymatic Behaviour of Chymotrypsin and Tryspin

Nature volume 205, pages 868–871 (1965)Cite this article

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References

  1. Hartley, B. S., Ann. Rev. Biochem., 29, 45 (1960).

    Article  CAS  Google Scholar 

  2. Compare with Balls, A. K., and Jansen, E. F., in Advances in Enzymology, 13, edit. by Nord, F. F., 321 (Interscience Publishers, Inc., New York, 1952).

    Google Scholar 

  3. Erlanger, B. F., and Cohen, W., J. Amer. Chem. Soc., 85, 358 (1963); Erlanger, B. F., Castleman, H., and Cooper, A. G., ibid., 85, 1872 (1963).

    Google Scholar 

  4. Inagami, T., and Sturtevant, J. M., J. Biol. Chem., 235, 1019 (1960).

    CAS  PubMed  Google Scholar 

  5. Bender, M. L., and Kaiser, E. T., J. Amer. Chem. Soc., 84, 2556 (1962).

    Article  CAS  Google Scholar 

  6. Schoellman, G., and Shaw, E., Biochem., 2, 252 (1963). Walsh, K. A., Kauffman, D. L., Sampath Kumar, K. S. V., and Neurath, H., Proc. U.S. Nat. Acad. Sci., 51, 301 (1964).

    Article  Google Scholar 

  7. Cohen, W., and Erlanger, B. F., J. Amer. Chem. Soc., 82, 3928 (1960). Cohen, W., Lache, M., and Erlanger, B. F., Biochem., 1, 686 (1962).

    Article  CAS  Google Scholar 

  8. Cunningham, L. W., J. Biol. Chem., 207, 443 (1954).

    CAS  PubMed  Google Scholar 

  9. Berends, F., Posthumus, C. H., Sluys, I. V. D., and Deierkauf, F. A., Biochim. Biophys. Acta, 34, 576 (1959).

    Article  CAS  Google Scholar 

  10. Jandorf, B. J., J. Amer. Chem. Soc., 78, 3686 (1956).

    Article  CAS  Google Scholar 

  11. Trowbridge, C. G., Krehbiel, A., and Laskowski, jun., M., Biochem., 2, 843 (1963).

    Article  CAS  Google Scholar 

  12. Inagami, T., and Murachi, T., J. Biol. Chem., 238, PC 1905 (1963).

    CAS  PubMed  Google Scholar 

  13. Erlanger, B. F., and Castleman, H., Biochim. Biophys. Acta, 85, 507 (1964).

    CAS  PubMed  Google Scholar 

  14. Hartley, B. S., Nature, 201, 1284 (1964).

    Article  ADS  CAS  Google Scholar 

  15. Kupcham, Morris S., Eriksen, S. P., and Friedman, M., J. Amer. Chem. Soc., 84, 4159 (1962).

    Article  Google Scholar 

  16. Bender, M. L., and Kaiser, E. T., J. Amer. Chem. Soc., 84, 2556 (1962).

    Article  CAS  Google Scholar 

  17. Bender, M. L., Schonbaum, G. R., and Zerner, B., J. Amer. Chem. Soc., 84, 2562 (1962).

    Article  Google Scholar 

  18. Bender, M. L., Clement, G. E., Kezdy, F. J., and Heck, H. d'A., J. Amer. Chem. Soc., 86, 3680 (1964).

    Article  CAS  Google Scholar 

  19. Jansen, E. F., Curl, A. L., and Balls, A. K., J. Biol. Chem., 189, 671 (1951).

    CAS  PubMed  Google Scholar 

  20. Cohen, W., and Erlanger, B. F., Biochim. Biophys. Acta, 52, 604 (1961).

    Article  CAS  Google Scholar 

  21. Labouesse, B., Oppenheimer, H. L., and Hess, G. P., Biochem. Biophys. Res. Commun., 14, 318 (1964).

    Article  CAS  Google Scholar 

  22. Erlanger, B. F., Kokowsky, N., and Cohen, W., Arch. Biochem. Biophys., 95, 271 (1961).

    Article  CAS  Google Scholar 

  23. Wilson, I. B., and Erlanger, B. F., J. Amer. Chem. Soc., 82, 6422 (1960).

    Article  CAS  Google Scholar 

Download references

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Author notes

  1. WILLIAM COHEN

    Present address: Department of Biochemistry, Tulane University Medical School, New Orleans, La

Authors and Affiliations

  1. Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, 32, N.Y.

    BERNARD F. ERLANGER,  WILLIAM COHEN, SPYROS M. VRATSANOS, HARRIET CASTLEMAN & A. G. COOPER

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  1. BERNARD F. ERLANGER
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  2. WILLIAM COHEN
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  3. SPYROS M. VRATSANOS
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  4. HARRIET CASTLEMAN
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  5. A. G. COOPER
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ERLANGER, B., COHEN, W., VRATSANOS, S. et al. Postulated Chemical Basis for Observed Differences in the Enzymatic Behaviour of Chymotrypsin and Tryspin. Nature 205, 868–871 (1965). https://doi.org/10.1038/205868a0

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