Abstract
SEVERAL cases of moderately severe hypochromic hæmolytic anæmia have recently been observed in Burgas, Bulgaria1. The affected individuals were unrelated white adult men and women. They showed splenomegaly, slight icterus, decreased osmotic fragility of the red cells and 40–90 per cent target cells. Paper and starch-gel electrophoresis2 at pH 8.6 of their hæmoglobin showed complete absence of normal adult hæmoglobin (Hb A) and presence of a slow-moving abnormal hæmoglobin. The electrophoretic mobility of this abnormal hæmoglobin was similar in paper electrophoresis to that of hæmoglobin C (Hb C). In starch-gel electrophoresis the abnormal hæmoglobin moves slightly ahead of Hb C. In agar-gel electrophoresis at pH 6.03 it moved between Hb A and Hb C, in the position of hæmoglobin S (Fig. 1).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Kantchev, K. N., and Tcholakov, B., Archiv. Union. Med. Balk. (in the press).
Poulik, M. D., Nature, 180, 1477 (1957).
Robinson, A. R., Robson, M., Harrison, A. P., and Zuelzer, A. W., J. Lab. Clin. Med., 50, 745 (1957).
Ingram, V. M., Biochim. Biophys. Acta, 28, 539 (1958).
Baglioni, C., Biochim. Biophys. Acta, 48, 392 (1961).
Baglioni, C., and Lehmann, H., Nature, 196, 229 (1962).
Ingram, V. M., and Stretton, A. O. W., Nature, 190, 1079 (1961).
Ramot, B., Fisher, S., Remez, D., Schneerson, R., Kahane, D., Ager, J. A. M., and Lehmann, H., Brit. Med. J., ii, 1262 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KANTCHEV, K., TCHOLAKOV, B., BAGLIONI, C. et al. Hæmoglobin OArab in Bulgaria. Nature 205, 187–188 (1965). https://doi.org/10.1038/205187a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/205187a0
This article is cited by
-
The interaction of hemoglobin O Arab with Hb S and β+ thalassemia among Israeli Arabs
Human Genetics (1985)
-
Haemoglobin O Arab in Sudanese
Nature (1966)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.