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Selective inhibition of neurite outgrowth on mature astrocytes by Thy-1 glycoprotein

Nature volume 355, pages 745–748 (1992)Cite this article

Abstract

THY-1, the smallest member of the immunoglobulin superfamily1, is a major cell-surface component expressed by several tissues2. The protein1carbohydrate3 and gene4 structures of this molecule are known, yet its function is not. It is highly expressed in nervous tissue5, where it appears on virtually all neurons after the cessation of axonal growth6. Here we show that expression of Thy-1 by a neural cell line inhibits neurite outgrowth on mature astrocytes, but not on other cellular substrata which include Schwann cells and embryonic glia. This inhibition of neurite extension on astrocytes can be reversed by low concentrations (nanomolar) of soluble Thy-1. If a similar interaction between neuronal Thy-1 and astrocytes occurs in vivo, it could stabilize neuronal connec-tions and suppress axonal regrowth after injury in the astrocyte-rich areas of adult central nervous system.

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Authors and Affiliations

  1. Norman and Sadie Lee Research Centre, Laboratory of Neurobiology, London, NW7 1AA, UK

    Marie-Catherine Tiveron, F. Bernardo Pliego Rivero, Ann Marie Gormley, P. John Seeley & Roger Morris

  2. Laboratory of Gene Structure and Expression, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    Erminia Barboni

  3. Department of Human Biopathology, Facolta di Medicina e Chirurgia, University of Rome 'La Sapienza', Rome, Italy

    Frank Grosveld

Authors
  1. Marie-Catherine Tiveron
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  2. Erminia Barboni
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  3. F. Bernardo Pliego Rivero
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  4. Ann Marie Gormley
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  5. P. John Seeley
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  6. Frank Grosveld
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  7. Roger Morris
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Tiveron, MC., Barboni, E., Pliego Rivero, F. et al. Selective inhibition of neurite outgrowth on mature astrocytes by Thy-1 glycoprotein. Nature 355, 745–748 (1992). https://doi.org/10.1038/355745a0

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