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Neuronally mediated non-cholinergic contraction of guineapig bronchial smooth muscle is inhibited by a substance P antagonist

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Abstract

The isolated main bronchi of the guinea-pig respond to electrical field stimulation with a twitch followed by a slow contraction. Atropine blocked the slow contraction. The substance P antagonist, (d-Pro2,d-Trp7.9)-SP, greatly reduced the atropine-resistant contraction. The results suggest the involvement of substance P in non-cholinergic neurotransmission in the guinea-pig airways.

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Authors and Affiliations

  1. Department of Pharmacology, University of Lund, Lund, Sweden

    S. Leander & R. Håkanson

  2. Department of Pharmacology, University of Linköping, Linköping, Sweden

    N. Grundström & R. G. G. Andersson

Authors
  1. S. Leander
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  2. N. Grundström
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  3. R. G. G. Andersson
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  4. R. Håkanson
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Leander, S., Grundström, N., Andersson, R.G.G. et al. Neuronally mediated non-cholinergic contraction of guineapig bronchial smooth muscle is inhibited by a substance P antagonist. Agents and Actions 14, 315–318 (1984). https://doi.org/10.1007/BF01973819

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  • DOI: https://doi.org/10.1007/BF01973819

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