Abstract
A significant correlation between the degree of bronchial reactivity to ACH, Hi and A.E. was found in a series of 23 dogs. An increase in receptors sensitivity responsible for the organic manifestation of allergy must be assumed. This increased receptors sensitivity is an important phenomenon in asthma clinically relevant.
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References
D.H. Bryant andM.W. Burns,Bronchial histamine reactivity, its relationship to the reactivity of the bronchi to allergens, Clin. Allergy6, 523–532 (1976).
H. Herxheimer,Bronchial obstruction induced by allergens, histamine and acetyl-beta-methyl-choline, Int. Arch. Allergy2, 27 (1951).
R.S. Hogarth-Scott,The molecular weight range of nematode allergens, Immunology13, 535 (1967).
M.S. Islam andW.T. Ulmer,Lokale Überemfindlichkeit sensorischer Rezeptoren als Ursache reflektorischer Atemwegsobstruktion, Respirtion32, 445 (1975).
J.A. Nadel,Structure-function relationships in the airways: Bronchoconstriction mediated via vagus nerves or bronchial arteries. Peripheral lung constriction mediated via pulmonary arteries, Med. Thorac.22, 861 (1962).
B.G. Simonsson, F.M. Jabkobs andJ.A. Nadel,Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airway disease, J. clin. Invest.46, 1812 (1967).
R. Tiffeneau,De l'allergie pulmonaire a l'hyperexitalité bronchomotorique de l'asthmatique, Presse Méd.67, 2017 (1959).
J.G. Widdicombe, D.C. Kent andJ.A. Nadel,Mechanism of bronchoconstriction during inhalation of dust, J. appl. Physiol.17, 613 (1962).
J.G. Widdicombe andG.M. Sterling,The automatic nervous system and breathing, Archs. intern. Med.126, 311–329 (1970).
I. Zimmermann, M.A. Haxhiu, A.A. Bugalho de Almeida andW.T. Ulmer,Localisation of the changes of the sensitivity of the airways by proteolytic enzymes (Pronase) against acetylcholine, Respiration38, 249–256 (1979).
I. Zimmermann, A.A. Bugalho de Almeida andW. T. Ulmer, The role of action of aβ-receptor stimulating drug (Fenoterol) on antigen-induced bronchoconstriction, Lung158, 15–23 (1980a).
I. Zimmermann, A.A. Bugalho de Almeida andW.T. Ulmer,Allergeninduzierte Atemwegsobstruktion und Histaminkonzentration im arteriellen wie venösen Plasma, I. Mitteilung, Res. Exp. Med.177, 91–100 (1980b).
I. Zimmermann, A.A. Bugalho de Almeida, W. T. Ulmer andS.H. Park,Histamine release into tracheal lumen and bronchial reactivity. Effect of local allergen administration on histamine release and bronchial reactivity, Res. Exp. Med.182, 153–166 (1983).
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Zimmermann, I., Bugalho de Almeida, A.A. & Ulmer, W.T. The correlation between allergen, acetylcholine and histamine-induced bronchoconstriction. Agents and Actions 15, 474–477 (1984). https://doi.org/10.1007/BF01966758
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DOI: https://doi.org/10.1007/BF01966758