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Histamine involvement in the local and systemic microvascular effects produced by intradermal substance P

  • Histamine and Kinins
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Abstract

The cutaneous microvascular changes produced by intradermal substance P were quantitatively evaluated in both substance P-injected and contralateral, saline-injected guinea pig ears. Substance P evoked a dose-dependent increase in cutaneous microvascular permeability in both treated and untreated ears which was reduced, but not abolished, by a mepyramine-cimetidine combination. This indicates that the local effect of substance P on microvascular permeability and the effect on the contralateral ear (presumably the result of systemic substance P absorption) are both partially mediated by histamine. A cutaneous vasodilator response was also observed in substance P treated and contralateral ears, but a bell-shaped dose-response relationship was apparent. Unlike microvascular permeability, pretreatment with mepyramine and cimetidine failed to consistently attenuate the vasodilator response to substance P. Thus, a direct cutaneous vasodilator effect appars to predominate in both substance P-injected and saline-injected ears.

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Authors and Affiliations

  1. Dept. of Pharmacology, Allergan Pharmaceuticals, Irvine, CA, U.S.A.

    D. F. Woodward, D. A. A. Owen, M. A. Pipkin & S. E. Ledgard

  2. Dept. of Pharmacology, Smith, Kline & French Research, Ltd., Welwyn, England

    D. F. Woodward, D. A. A. Owen, M. A. Pipkin & S. E. Ledgard

Authors
  1. D. F. Woodward
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  2. D. A. A. Owen
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  3. M. A. Pipkin
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  4. S. E. Ledgard
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Woodward, D.F., Owen, D.A.A., Pipkin, M.A. et al. Histamine involvement in the local and systemic microvascular effects produced by intradermal substance P. Agents and Actions 17, 126–130 (1985). https://doi.org/10.1007/BF01966580

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